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首页> 外文期刊>Infection and immunity >Intracerebral Inoculation of Rhesus Monkeys with a Strain of Measles Virus Isolated from a Case of Subacute Sclerosing Panencephalitis
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Intracerebral Inoculation of Rhesus Monkeys with a Strain of Measles Virus Isolated from a Case of Subacute Sclerosing Panencephalitis

机译：从一例亚急性硬化性全脑炎分离出的麻疹病毒株对恒河猴的脑内接种

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Measles virus isolated from the brain of a patient with subacute sclerosing panencephalitis was injected intracerebrally (ic) into 34 rhesus monkeys. Groups of these animals were injected with measles antigen in Freund's complete adjuvant or treated by schedules used for suppression of the general or cell-mediated immune responsiveness. In another group of animals, experimental allergic encephalitis was induced parallel with measles infection. Measles virus was isolated from the brains of monkeys up to 13 days after ic inoculation. No virus was detected in the central nervous system after 3 to 4 weeks, the longest postinoculation period examined. It was concluded that the subacute sclerosing panencephalitis-derived virus either lost its neurotropic properties at the passage level at which it was used or that it submerged into a silent stage and escaped detection. Neither immunosuppression nor concomitant autoimmune encephalitis had an effect on the survival of measles virus in the central nervous system. The histology of the nervous tissue was basically normal except for characteristic lesions of experimental allergic encephalitis in animals receiving the respective treatment.
机译：从亚急性硬化性全脑炎患者脑中分离出的麻疹病毒经脑内（ic）注入34只恒河猴中。给这些动物的组注射弗氏完全佐剂中的麻疹抗原，或按照用于抑制一般或细胞介导的免疫应答的方案进行治疗。在另一组动物中，实验性过敏性脑炎与麻疹感染同时发生。 ic接种后长达13天，从猴子的大脑中分离出了麻疹病毒。在最长的接种后3至4周后的中枢神经系统中未检测到病毒。结论是，亚急性硬化性全脑炎病毒在使用的传代水平上丧失了其嗜神经性，或者浸入了沉默阶段并逃脱了检测。免疫抑制和伴随的自身免疫性脑炎都不会影响麻疹病毒在中枢神经系统中的存活。除了接受相应治疗的动物实验性过敏性脑炎的特征性病变外，神经组织的组织学基本正常。

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