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首页> 外文期刊>Infection and immunity >Immunotherapy of Cancer with Nonliving BCG and Fractions Derived from Mycobacteria: Role of Cord Factor (Trehalose-6, 6′-Dimycolate) in Tumor Regression
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Immunotherapy of Cancer with Nonliving BCG and Fractions Derived from Mycobacteria: Role of Cord Factor (Trehalose-6, 6′-Dimycolate) in Tumor Regression

机译：非活性卡介苗和分枝杆菌衍生片段对癌症的免疫治疗：脐带因子（海藻糖6、6'-二甲双酚）在肿瘤消退中的作用

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Delipidated and deproteinized cell walls from Mycobacterium tuberculosis H37Ra suspended in 1.25% mineral oil emulsion cured established tumors in the skin and metastases in draining lymph nodes of guinea pigs (strain 2) after intratumoral administration in 33% of the cases examined. This was increased to 83% when a mixture of cord factor and the delipidated cell walls was used. A similarly high percentage of cures was obtained after administration of lyophilized, killed BCG alone or with addition of cord factor in 1% mineral oil emulsion. Lyophilized, killed BCG dispersed in a solution of tocopherol acetate in peanut oil or in peanut oil alone showed a limited tumor-regressive activity (36%). However, a mixture of BCG and cord factor suspended in the above media cured 80 and 69% of the treated animals, respectively.
机译：悬浮于1.25％矿物油乳剂中的结核分枝杆菌 H37Ra的细胞壁脱脂和去蛋白，治愈了33％的肿瘤内给药后豚鼠引流的淋巴结（2株）中已形成的皮肤肿瘤和转移灶。案件进行了审查。当使用脐带因子和脱脂细胞壁的混合物时，该比例增加到83％。单独施用冻干的，杀死的BCG或在1％的矿物油乳液中添加脐带因子后，可获得相似高的治愈率。冻干的杀死的BCG分散在生育酚乙酸酯的花生油或仅花生油的溶液中显示出有限的肿瘤消退活性（36％）。但是，悬浮在上述培养基中的BCG和脐带因子的混合物分别治愈了80％和69％的治疗动物。

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