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首页> 外文期刊>Infection and immunity >Antigenicity of type-specific pneumococcal polysaccharides in rats.
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Antigenicity of type-specific pneumococcal polysaccharides in rats.

机译：类型特异性肺炎球菌多糖在大鼠中的抗原性。

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摘要

Hemagglutinating antibody responses of Lewis-Wistar and Sprague-Dawley rats to graded doses of type-specific pneumococcal polysaccharide were measured. Rats given a small dose (0.2 to 50 mug)of type 1 or 8 polysaccharide intraperitoneally developed type-specific hemagglutinating antibody. Rats given larger doses of polysaccharide (greater than or equal to200 mug) did not develop detectable hemagglutinating antibody, and they were unresponsive to a subsequence injection of a small (and normally antigenic) dose of polysaccharide. There was prolonged antigenemia in rats injected with a large dose of polysaccharide. There was prolonged antigenemia in rats injected with a large dose of polysaccharide, and the kinetics of antigen clearance in these animals resembled that reported for mice with polysaccharide immunological paralysis. These results indicate that a phenomenon resembling immunological paralysis with type-specific pneumococcal polysaccharides can be produced in rats.
机译：测量了Lewis-Wistar和Sprague-Dawley大鼠对分级剂量的类型特异性肺炎球菌多糖的血凝抗体反应。给予小剂量（0.2至50杯）1型或8型多糖的大鼠腹膜内发育的类型特异性血凝抗体。给予较大剂量多糖（大于或等于200马克杯）的大鼠未发育出可检测到的血凝抗体，并且对随后注射小剂量（通常是抗原性）多糖没有反应。注射了大剂量多糖的大鼠体内抗原血症延长。注射了大剂量多糖的大鼠体内的抗原血症延长，这些动物体内抗原清除的动力学类似于多糖免疫麻痹小鼠的报道。这些结果表明可以在大鼠中产生类似于具有类型特异性肺炎球菌多糖的免疫麻痹的现象。

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