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Hereditary Characteristic that Varies Among Isolates of Mycobacterium leprae

机译：麻风分枝杆菌分离株之间存在差异的遗传特征

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Isolates of Mycobacterium leprae in mouse foot pads were found to differ in two related properties, the average rate of growth between inoculation and harvest (G) and the number of bacilli in the harvest (H). For “fast” strains the median values for G were less than 25 days per generation, and the median values for H were above 106.1. For “slow” strains the median values for G were above 30, and the median values for H were below 105.6. The G and H values for the 59 isolates for which data were available formed a continuous spectrum between the two extremes; there was no correlation with dapsone resistance. The fastness characteristic was stable; it did not change on passage in mice and was in agreement when more than one isolate had been made from the same patient. No important differences were apparent according to geographic origin of the infection of the patient. Histological studies showed that fast strains grew to a higher level without inducing the infiltrate of lymphocytes and macrophages that appears at the end of the logarithmic phase of growth in mouse foot pads. Although fast strains often had higher ratios of solidly staining (and presumably viable) bacilli in the inoculum, the fast-slow difference was not accounted for by the solid ratio. Slow strains differed from fast by having longer times until harvest and by having fewer generations of growth, even when their frequently lower solid ratios were taken into account.
机译：发现小鼠脚垫中的麻风分枝杆菌分离株在两个相关特性方面有所不同，即接种和收获之间的平均生长速率（ G ）和鸡中细菌的数量。收获（ H ）。对于“快速”菌株，每代 G 的中值小于25天，而 H 的中值大于10 6.1 。对于“慢”菌株， G 的中值高于30，而 H 的中值低于10 5.6 。可获得数据的59个分离株的 G 和 H 值在两个极端之间形成了连续光谱。与氨苯砜耐药没有相关性。牢度特性稳定;它在小鼠体内的传代过程中没有改变，并且与同一名患者分离出一种以上的分离株相一致。根据患者感染的地理来源，没有明显差异。组织学研究表明，快速的菌株生长到更高的水平，而不会诱导淋巴细胞和巨噬细胞的浸润，而这种浸润是在小鼠足垫生长的对数生长期结束时出现的。尽管快速菌株通常在接种物中具有较高的固色细菌比例（并且推测是可行的），但固相比例不能解释快速-慢速差异。慢菌株与快菌株的不同之处在于，即使考虑到它们通常较低的固形比，也需要更长的时间才能收获，并且生长的世代更少。

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