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首页> 外文期刊>Infection and immunity >Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds.
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Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds.

机译：分枝杆菌级分的佐剂活性：合成的N-乙酰基村yl基二肽和相关化合物的佐剂活性。

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Immunological activity of synthetic cell wall peptidoglycan subunits was examined in guinea pigs and mice. It was concluded that the minimal adjuvant-active subunit of cell wall peptidoglycan for the induction of delayed-type hypersensitivity to monoazobenzenearsonate-N-acetyl-L-tyrosine and for circulating-antibody formation to bacterial alpha-amylase and the thymus-independent antigen DNP-Ficoll was N-acetylmuramyldipeptide, MurNAc-L-Ala-D-isoGln. N-acetylmuramyldipeptide and 6-O-stearoyl-N-acetylmuramyldipeptide showed no adjuvant activity in the generation of cell-mediated cytotoxic effector cells in the spleens of C57Bl/6J mice after in vivo immunization with the allogeneic antigen mastocytoma P815-X2 cells, but N-acetylmuramyldipeptide showed adjuvant activity after in vitro sensitization of C57Bl/6J mouse spleen cells to the alloantigen mitomycin C-treated DBA/2 mouse spleen cells. It was also shown that 6-O-stearoylation of N-acetylmuramylpeptide could not potentiate the adjuvant activity of N-acetylmuramyldipeptide. Mitogenic and antitumor activities were not observed in either N-acetylmuramyldipeptide or 6-O-stearoyl-N-acetylmuramyldipeptide in mouse systems.
机译：在豚鼠和小鼠中检查了合成细胞壁肽聚糖亚基的免疫活性。结论是细胞壁肽聚糖的最小佐剂活性亚基可诱导对单偶氮苯磺酸盐-N-乙酰基-L-酪氨酸的迟发型超敏反应以及对细菌α-淀粉酶和胸腺非依赖性抗原DNP的循环抗体形成。 -Ficoll为N-乙酰基村酰胺基肽，MurNAc-L-Ala-D-isoGln。同种异体抗原肥大细胞瘤P815-X2细胞体内免疫后，在C57Bl / 6J小鼠脾脏中，N-乙酰基村酰肽和6-O-硬脂酰-N-乙酰基村酰肽在细胞介导的细胞毒性效应细胞的产生中没有显示佐剂活性，但是在将C57Bl / 6J小鼠脾细胞对同种抗原丝裂霉素C处理的DBA / 2小鼠脾细胞进行体外致敏后，N-乙酰基muramyldipeptide具有佐剂活性。还显示出N-乙酰基村my肽的6-O-硬脂酰化不能增强N-乙酰基村mura肽的佐剂活性。在小鼠系统中，在N-乙酰基村酰间肽或6-O-硬脂酰-N-乙酰基村酰间肽中均未观察到有丝分裂和抗肿瘤活性。

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