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首页> 外文期刊>Infection and immunity >Adjuvant activity of synthetic 6-O-'mycoloyl'-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds.
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Adjuvant activity of synthetic 6-O-'mycoloyl'-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds.

机译：合成的6-O-“霉菌酰基” -N-乙酰基村酰基-L-丙氨酰基-D-异谷氨酰胺和相关化合物的佐剂活性。

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摘要

Adjuvant and antitumor activities of synthetic 6-O-"mycoloyl"-N-acetylmuramyl-L-alanyl-D-isoglutamine were examined. All the synthetic 6-O-corynomycoloyl-, 6-O-mocardomycoloyl-, and 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine were active as adjuvants for cell-mediated immune responses. However, 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine was less active as an adjuvant on circulating antibody formation. It was shown that pyrogenic activity of N-acetylmuramyldipeptide was reduced by 6-O-acylation with mycolic acid, but not with nocardomycolic or corynomycolic acid. Tumor-suppression activity was observed by the synthetic 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine by using transplantable tumor in syngenic mice.
机译：检查了合成的6-O-“霉菌酰基” -N-乙酰基村酰基-L-丙氨酰基-D-异谷氨酰胺的佐剂和抗肿瘤活性。所有合成的6-O-corynomycoloyl-，6-O-momoomyomycoloyl-和6-O-mycoloyl-N-乙酰基村m基-L-丙氨酰-D-异谷氨酰胺均具有活性，可作为细胞介导的免疫应答的佐剂。然而，6-O-麦考洛基-N-乙酰基村酰胺基-L-丙氨酰基-D-异谷氨酰胺作为佐剂在循环抗体形成中的活性较低。结果表明，通过6-O-酰化与霉菌酸可降低N-乙酰基muramyldipeptide的热解活性，而对于非霉菌酸或胭脂红酸则不会。通过在同基因小鼠中使用可移植的肿瘤，通过合成的6-O-羟甲基-N-乙酰基村酰胺基-L-丙氨酰基-D-异谷氨酰胺观察到了肿瘤抑制活性。

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