Heat-labile enterotoxin production in isolates from a shipboard outbreak of human diarrheal illness.

K Wachsmuth; J Wells; P Shipley; R Ryder

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Heat-labile enterotoxin production in isolates from a shipboard outbreak of human diarrheal illness.

机译：从人类腹泻病的船上爆发中分离出的热不稳定性肠毒素产生。

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As reported elsewhere, an enterotoxigenic strain of Escherichia coli serotype O25:K98:NM was epidemiologically incriminated as the etiological agent in a shipboard outbreak of diarrheal illness. This enterotoxigenic E. coli strain and possibly other enteric isolates were found to produce heat-labile toxin and not heat-stable toxin. Since previous genetic analyses of enterotoxigenic E. coli strains producing heat-labile and heat-stable toxins have shown a plasmid location for both toxin determinants and since in this outbreak more than one bacterial strain appeared to produce only heat-labile toxin, the possibility of an extrachromosomal heat-labile toxin determinant was investigated. Results of endonuclease cleavage and hybridization experiments, as well as apparent heat-labile toxin phenotypic instability, strongly suggest a plasmid mediation of toxin production. Additionally, the stability of this heat-labile toxin production was evaluated after several traditional methods of bacterial cell preservation.

机译：如在其他地方报道的，在船上腹泻病暴发中，在流行病学上将大肠杆菌血清型O25：K98：NM的产肠毒素菌株归因于病原体。发现这种产肠毒素的大肠杆菌菌株和可能的其他肠道分离株会产生热不稳定毒素，而不是热稳定毒素。自从以前对产热不稳定和热稳定毒素的产肠毒素大肠杆菌菌株进行遗传分析以来，该菌株已显示出两种毒素决定簇的质粒位置，并且由于在这一暴发中，不止一种细菌菌株似乎仅产生对热不稳定的毒素，因此有可能研究了染色体外热不稳定毒素决定簇。核酸内切酶切割和杂交实验的结果，以及明显的热不稳定毒素表型不稳定性，强烈提示质粒介导了毒素的产生。另外，在几种传统的细菌细胞保存方法之后，评估了这种热不稳定毒素产生的稳定性。

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《Infection and immunity》 |1979年第3期|共5页
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K Wachsmuth; J Wells; P Shipley; R Ryder;
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1. Heat-labile enterotoxin production in isolates from a shipboard outbreak of human diarrheal illness. [J] . K Wachsmuth, J Wells, P Shipley, Infection and immunity . 1979,第3期

机译：从人类腹泻病的船上爆发中分离出的热不稳定性肠毒素产生。
2. Species specificity and lack of production of STb enterotoxin by Escherichia coli strains isolated from humans with diarrheal illness. [J] . C S Weikel, K M Tiemens, S L Moseley, Infection and immunity . 1986,第1期

机译：从具有腹泻病的人分离的大肠杆菌菌株的种类特异性和缺乏STb肠毒素的产生。
3. The Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb and Their Respective B Pentamers Differentially Induce and Regulate Cytokine Production in Human Monocytic Cells [J] . George Hajishengallis, Hesham Nawar, Richard I. Tapping, Infection and immunity . 2004,第11期

机译：II型不耐热肠毒素LT-IIa和LT-IIb及其各自的B五聚体差异地诱导和调节人单核细胞中细胞因子的产生。
4. Enterotoxin genes in Staphylococcus aureus isolates from pork and pigs [C] . Danielle Botting, Peter Davies, Leticia Linhares, Annual^Meeting of the American Association^of^Swine^Veterinarians. . 2013

机译：在猪肉和猪的金黄色葡萄球菌的肠毒素基因
5. Secretion of heat-labile enterotoxin by porcine-origin enterotoxigenic Escherichia coli and relation to virulence. [D] . Wijemanne, Prageeth Rukshan. 2015

机译：猪源产肠毒素的大肠杆菌分泌不耐热肠毒素及其与毒力的关系。
6. Heat-labile enterotoxin production in isolates from a shipboard outbreak of human diarrheal illness. [O] . K Wachsmuth, J Wells, P Shipley, 1979

机译：从人类腹泻病的船上爆发中分离出的热不稳定性肠毒素产生。
7. Novel Type II Heat-Labile Enterotoxin Produced by Human Disease Outbreak Isolates of Escherichia coli Is a Member of the LT-IIa Family and Should Not Form a New Group: Clarification of Nomenclature and Precedent [O] . Michael G Jobling 2020

机译：新型II型由人类疾病爆发的热稳定肠毒素爆发了大肠杆菌的分离株是LT-IIA家族的成员，不应形成新组：澄清名称和先例
8. Type II Heat-Labile Enterotoxin-Producing 'Escherichia coli' Isolated from Animals and Humans [R] . Seriwatana, J., Echeverria, P., Taylor, D. N., 1988

机译：从动物和人类中分离的II型热不稳定肠毒素产生'大肠杆菌'

Heat-labile enterotoxin production in isolates from a shipboard outbreak of human diarrheal illness.

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