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Effect of Bactericidal Substance from Staphylococcus aureus on Group A Streptococci I. Biochemical Alterations

机译:金黄色葡萄球菌的杀菌物质对A组链球菌的影响I.生化改变

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A bactericidal substance isolated from phage type 71 staphylococci has been studied relative to its mechanism of action on streptococcal cells. The substance exerts its effect best at 37 C. No cell lysis occurs as evidenced by lack of alteration in optical density of susceptible cell suspensions. The bactericidal substance results in immediate cessation of protein and deoxyribonucleic acid synthesis as well as degradation of newly and previously formed ribonucleic acid (RNA). The action on RNA seems to be independent of protein synthesis.
机译:从噬菌体71型葡萄球菌分离出的杀菌物质已经对其链球菌细胞的作用机理进行了研究。该物质在37°C时发挥最佳效果。没有细胞裂解发生,如易感细胞悬液的光密度缺乏变化所证明。该杀菌物质导致蛋白质和脱氧核糖核酸合成的立即停止以及新的和先前形成的核糖核酸(RNA)的降解。对RNA的作用似乎与蛋白质合成无关。

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