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首页> 外文期刊>Infection and immunity >Immunological Study of Typhoid: Immunoglobulins, C3, Antibodies, and Leukocyte Migration Inhibition in Patients with Typhoid Fever and TAB-Vaccinated Individuals
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Immunological Study of Typhoid: Immunoglobulins, C3, Antibodies, and Leukocyte Migration Inhibition in Patients with Typhoid Fever and TAB-Vaccinated Individuals

机译：伤寒的免疫学研究：伤寒和TAB疫苗接种患者的免疫球蛋白，C3，抗体和白细胞迁移抑制

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摘要

The development of humoral and cell-mediated immune responses to Salmonella typhi antigens and immunoglobulin and C3 levels were determined in patients suffering from typhoid fever, TAB-vaccinated individuals, and appropriate controls. In 45 patients with typhoid, a significant elevation of immunoglobulin M (IgM) level was noted from the first week of illness onwards. Eighteen TAB-vaccinated persons also showed a significant elevation of IgM levels. In typhoid sera, the anti-O and anti-H antibodies were mostly 2-mercaptoethanol (2-ME) sensitive. The rise of IgM level correlated well with the 2-ME-sensitive anti-O and anti-H antibodies seen in typhoid patients. The anti-O antibodies in the TAB-vaccinated group were almost entirely 2-ME sensitive, but both 2-ME-sensitive and -resistant anti-H antibodies were detected in the TAB group. A marked increas in C3 level was also noted in patients with typhoid. The cell-mediated immunity (CMI), as measured by leukocyte migration inhibition tests, was demonstrable in 15 of 22 patients with typhoid. On the other hand, only 8 of the 20 normal subjects, 5 of the 16 fever control cases, and 6 of the 18 TAB-vaccinated individuals gave a positive CMI. The latter three groups were comparable with each other but were significantly different from the typhoid patients. It was concluded that TAB-vaccination did not induce CMI even though it induced the development of antibodies, the latter being comparable with those of the patients with typhoid. The significance of these findings is discussed.
机译：确定了伤寒患者，接种TAB疫苗的患者是否适当，对伤寒沙门氏菌抗原和免疫球蛋白及C 3 的体液免疫和细胞介导的免疫反应的发展。控制。从患病的第一周开始，在45名伤寒患者中，免疫球蛋白M（IgM）水平显着升高。 18名接受TAB疫苗接种的人也显示出IgM水平的显着升高。在伤寒血清中，抗O和抗H抗体大多对2-巯基乙醇（2-ME）敏感。 IgM水平的升高与伤寒患者中对2-ME敏感的抗O和抗H抗体的相关性很好。 TAB疫苗接种组中的抗O抗体几乎完全对2-ME敏感，但在TAB组中检测到了2-ME敏感和抗性的抗H抗体。伤寒患者的C 3 水平也明显升高。通过白细胞迁移抑制试验测得的细胞介导的免疫（CMI）在22名伤寒患者中有15名得到证实。另一方面，在20例正常受试者中，只有8例，16例发烧对照病例中的5例以及18例TAB疫苗接种者中有6例的CMI呈阳性。后三组彼此可比，但与伤寒患者明显不同。结论是，TAB疫苗接种即使诱导抗体的产生也不会诱导CMI，后者与伤寒患者相当。讨论了这些发现的意义。

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