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首页> 外文期刊>Infection and immunity >Immunological and serological diversity of Neisseria gonorrhoeae: gonococcal serotypes and their relationship with immunotypes.
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Immunological and serological diversity of Neisseria gonorrhoeae: gonococcal serotypes and their relationship with immunotypes.

机译：淋病奈瑟菌的免疫学和血清学多样性：淋球菌血清型及其与免疫型的关系。

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摘要

Strains of gonococcus were shown to be immunologically heterologous. Serum bactericidal activity generally correlated with induced immunity to gonococcal challenge as detected by the guinea pig subcutaneous chamber model. Sera devoid of bactericidal activity reflected the lack of cross-protection in subcutaneous chambers. Factors affecting the bactericidal assay described in this report include (i) source of complement, (ii) concentration of test antigen and complement activity, and (iii) presence of calcium and magnesium ions and bovine serum albumin in diluent. Poor correlation was observed between agglutinating activity of the immune sera and protection.
机译：淋球菌菌株在免疫学上是异源的。血清杀菌活性通常与豚鼠皮下腔室模型检测到的针对淋球菌攻击的诱导免疫力相关。缺乏杀菌活性的血清反映了皮下腔室缺乏交叉保护。影响本报告中描述的杀菌测定的因素包括：（i）补体来源，（ii）测试抗原的浓度和补体活性，以及​​（iii）稀释剂中钙和镁离子以及牛血清白蛋白的存在。在免疫血清的凝集活性和保护之间观察到差的相关性。

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