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首页> 外文期刊>Infection and immunity >Mycoplasma-dependent activation of normal lymphocytes: induction of a lymphocyte-mediated cytotoxicity for allogeneic and syngeneic mouse target cells.
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Mycoplasma-dependent activation of normal lymphocytes: induction of a lymphocyte-mediated cytotoxicity for allogeneic and syngeneic mouse target cells.

机译：正常淋巴细胞的支原体依赖性激活：对同种异体和同基因小鼠靶细胞诱导淋巴细胞介导的细胞毒性。

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摘要

Mycoplasma arthritidis, M. hominis, and M. arginini were tested for their ability to induce a cytotoxic response from normal CBA mouse lymphocytes against 51Cr-labeled allogeneic target cells. In most cases, the mycoplasmas alone were not toxic for the target cells. Furthermore, the mycoplasmas did not result in decreased lymphocyte viability but, in fact, contributed to enhanced lymphocyte survival. In the absence of normal CBA lymphocytes, mycoplasmas alone did not induce a significant amount of cell damage in either the allogeneic or the syngeneic target cells. Strains of M. arthritidis and M. hominis, when added to the lymphocyte-target cell mixtures, induced statistically significant increases in 51Cr release from both target cell types at each assay period after 6 h. The release of 51Cr was taken as a measure of cell death. M. arginini induced only low levels of cytotoxicity or none at all. Both arthritogenic and non-arthritogenic strains of M. arthritidis induced the cytotoxic response. The degree of cytotoxicity produced was directly related to the size of the initial inoculum. The presence or absence of serum in the culture medium did not contribute significantly to the cytotoxicity response.
机译：测试了支原体支原体，人型支原体和精子支原体对正常CBA小鼠淋巴细胞针对51Cr标记的同种异体靶细胞的细胞毒性反应的能力。在大多数情况下，仅支原体对靶细胞无毒。此外，支原体并未导致淋巴细胞活力降低，但实际上有助于提高淋巴细胞存活率。在缺乏正常的CBA淋巴细胞的情况下，单独的支原体不会在同种异体或同基因靶细胞中引起大量的细胞损伤。当将关节炎分枝杆菌和人型分枝杆菌菌株添加到淋巴细胞-靶细胞混合物中后，在6小时后的每个测定期间，从两种靶细胞类型中释放出51Cr的统计学显着增加。 51Cr的释放被视为细胞死亡的量度。精氨酸支原体仅诱导低水平的细胞毒性或根本不诱导细胞毒性。关节炎分枝杆菌的促关节炎和非促关节炎菌株均诱导细胞毒性反应。产生的细胞毒性程度与初始接种物的大小直接相关。培养基中血清的存在或不存在对细胞毒性反应没有显着贡献。

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