Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis.

E C Keystone; D Taylor-Robinson; M F Osborn; L Ling; C Pope; V Fornasier

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Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis.

机译：T细胞缺乏对肺炎支原体诱发的小鼠慢性关节炎的影响。

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Mycoplasma pulmonis inoculated parenterally into athymic nude mice congenitally deficient in T cells caused a chronic arthritis of significantly greater magnitude than in immunologically normal mice. During the chronic phase of arthritis, M. pulmonis organisms were isolated from the joints and spleens of athymic nude mice more frequently and in larger numbers than from immunologically normal mice. The results support the concept that impaired T-cell function predisposes the mice to a severe degree of chronic arthritis as a result of their failure to eliminate the causative organisms.

机译：先天性缺乏T细胞的无胸腺裸鼠肠胃外接种肺炎支原体引起的慢性关节炎的程度明显大于免疫正常小鼠。在关节炎的慢性阶段，与无免疫力的正常小鼠相比，从无胸腺裸鼠的关节和脾脏中分离出肺炎支原体的频率更高。结果支持了这样一个概念，即T细胞功能受损会导致小鼠因无法消除病原体而导致严重的慢性关节炎。

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《Infection and immunity》 |1980年第1期|共5页
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E C Keystone; D Taylor-Robinson; M F Osborn; L Ling; C Pope; V Fornasier;
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中图分类医学免疫学;
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1. Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis. [J] . E C Keystone, D Taylor-Robinson, M F Osborn, Infection and immunity . 1980,第1期

机译：T细胞缺乏对肺炎支原体诱发的小鼠慢性关节炎的影响。
2. New models of chronic synovitis in rabbits induced by mycoplasmas: microbiological, histopathological, and immunological observations on rabbits injected with Mycoplasma arthritidis and Mycoplasma pulmonis. [J] . B C Cole, M M Griffiths, E J Eichwald, Infection and immunity . 1977,第1期

机译：支原体诱发的兔慢性滑膜炎的新模型：注射了关节炎支原体和肺炎支原体的兔子的微生物学，组织病理学和免疫学观察。
3. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis: demonstration of a cell-mediated immune response to mycoplasma antigens in vitro. [J] . B C Cole, L Golightly-Rowland, J R Ward Infection and immunity . 1975,第5期

机译：由关节炎支原体引起的小鼠的慢性增生性关节炎：体外证明细胞介导的对支原体抗原的免疫反应。
4. Combinatorial, microparticle-based delivery of immune modulators reprograms dendritic cell phenotype and promotes remission of collagen-induced arthritis in mice [C] . Riley Allen, Shawn Chizari, Luke McKibbin, Society for Biomaterials annual meeting and exposition . 2019

机译：免疫调节剂的组合，基于微粒的递送重新编程树突状细胞表型，并促进小鼠胶原诱导的关节炎的缓解
5. Immunopathological airway remodeling in response to chronic infection with Mycoplasma pulmonis. [D] . Aurora, Arin Beth. 2004

机译：对肺炎支原体的慢性感染作出反应的免疫病理学气道重塑。
6. Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis. [O] . E C Keystone, D Taylor-Robinson, M F Osborn, 1980

机译：T细胞缺乏对肺炎支原体诱发的小鼠慢性关节炎的影响。
7. Effect of immunosuppression on arthritis in mice induced by Mycoplasma pulmonis. [O] . Taylor, G, Taylor-Robinson, D, Slavin, G 1974

机译：免疫抑制对肺炎支原体诱导的小鼠关节炎的影响。

Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis.

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