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Interferon Sensitivity of Venezuelan Equine Encephalomyelitis Virus

机译：委内瑞拉马脑脊髓炎病毒的干扰素敏感性

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Two strains of Venezuelan equine encephalomyelitis virus, which differ in virulence for mice, have been studied for their production of and sensitivity to chick and mouse interferon. Little interferon was produced by chick cells in response to the virulent Trinidad strain or the attenuated TC-83 strain without either aging or priming the cultures. Consistent differences in the production of chick interferon were not found between the two strains. Plaque variants of the Trinidad strain produced higher titers of mouse interferon than the TC-83 strain in both primed and control L-cell cultures. The TC-83 strain was found to be more sensitive than the Trinidad strain to the inhibitory effects of interferon. The greater sensitivity of the TC-83 strain was observed at both high and low multiplicities and for both chick and mouse interferons. These results are consistent with the hypothesis that interferon sensitivity may have a role as a determinant of virulence in some virus-host systems.
机译：已研究了两种委内瑞拉马脑脊髓炎病毒株，它们对小鼠的毒力不同，它们对小鸡和小鼠干扰素的产生及其敏感性。鸡细胞对有毒的特立尼达菌株或减毒的TC-83菌株产生的干扰素很少，而没有老化或引发培养物。两种菌株之间未发现小鸡干扰素产生的一致性差异。在初免和对照L细胞培养物中，特立尼达菌株的噬菌斑变体产生的小鼠干扰素滴度均高于TC-83菌株。发现TC-83菌株比特立尼达菌株对干扰素的抑制作用更敏感。 TC-83菌株在高和低多重性以及小鸡和小鼠干扰素中都具有更高的敏感性。这些结果与以下假设一致：干扰素敏感性可能在某些病毒宿主系统中起决定毒性作用。

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