...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Antibody Response of Hamsters to A2/Hong Kong Virus Vaccine after Priming by Heterotypic Virus Infection
【24h】

Antibody Response of Hamsters to A2/Hong Kong Virus Vaccine after Priming by Heterotypic Virus Infection

机译：异型病毒感染引发仓鼠对A2 /香港病毒疫苗的抗体应答

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hamsters previously infected with influenza virus A1/FM/1/47 produced serum hemagglutination inhibition (HI) antibody in response to 1/100 the antigenic dose of inactivated influenza virus A2/Hong Kong vaccine necessary to induce antibody in normal animals. This priming effect was believed to be due to the virus infection which caused an immune response to a virus antigen common to both the infecting virus and the virus vaccine; this antigen acted as a carrier for the specific vaccine virus hemagglutinin and potentiated the immune response to the new antigen. This theory, which has been established in other immune systems, was tested, and the results obtained did not contradict the conditions imposed in the above explanation. Thus, the priming effect could be transferred to normal hamsters by inoculation of spleen cells from virus-infected animals, and the HI antibody response to the virus vaccine was characteristic of a secondary response. The theory also required that the new antigen be coupled to the carrier protein; however, primed hamsters produced serum HI antibody after inoculation with ether-Tween-split virus vaccine, but there was no proof that this vaccine was completely dissociated.
机译：先前感染了流感病毒A1 / FM / 1/47的仓鼠会产生血清血凝抑制（HI）抗体，以响应正常动物中诱导抗体所必需的1/100灭活流感病毒A2 /香港疫苗的抗原剂量。人们认为这种引发作用是由于病毒感染引起的，该病毒引起了针对感染病毒和病毒疫苗共同的病毒抗原的免疫反应。该抗原充当特定疫苗病毒血凝素的载体，并增强了对新抗原的免疫反应。测试了在其他免疫系统中已经建立的这一理论，并且获得的结果与上述解释中施加的条件不矛盾。因此，可以通过接种被病毒感染的动物的脾细胞而将引发作用转移至正常仓鼠，并且对病毒疫苗的HI抗体反应是继发反应的特征。该理论还要求将新抗原与载体蛋白偶联。但是，接种仓鼠后，用醚吐温分裂病毒疫苗接种后可产生血清HI抗体，但没有证据表明该疫苗已完全解离。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号