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首页> 外文期刊>Infection and immunity >Prevention of Streptococcus mutans infection of tooth surfaces by salivary antibody in Irus monkeys (Macaca fascicularis).
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Prevention of Streptococcus mutans infection of tooth surfaces by salivary antibody in Irus monkeys (Macaca fascicularis).

机译：唾液抗体预防艾鲁斯猴（Macaca fascicularis）感染牙齿表面的变形链球菌感染。

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Four irus monkeys (Macaca fascicularis) were immunized with Streptococcus mutans 6715 killed cells and cell products by injection in the vicinity of the major salivary glands and by instillation into the parotid glands via the ducts. After immune group and a sham-immunized control group of monkeys were infected orally with viable strain 6715 organisms. Dental plaque samples were taken at intervals from the buccal and lingual grooves of the first permanent molars. These samples were evaluated for recovery of strain 6715 by cultural methods. In addition, individual samples were taken from 10 representative tooth surfaces and were evaluated by indirect immunofluorescent staining for strain 6715. Results showed that immune monkeys had fewer infected surfaces and fewer organisms on the infected surfaces than the control animals. These studies indicate that salivary antibody to cariogenic streptococci inhibits implantation of these organisms in dental plaque and may be protective against dental caries.
机译：通过在主要唾液腺附近注射并通过导管滴入腮腺，用变形链球菌6715杀死的细胞和细胞产物对四只爱猴（猕猴）进行免疫。免疫组和假免疫对照组的猴子在口服后感染了6715株活菌。从第一恒磨牙的颊和舌沟间隔采集牙菌斑样品。通过培养方法评估这些样品的菌株6715的回收率。此外，从10个代表性牙齿表面上采集了单个样本，并通过间接免疫荧光染色对6715菌株进行了评估。结果显示，免疫猴子比对照组动物具有更少的感染表面和更少的生物。这些研究表明，针对龋齿链球菌的唾液抗体可抑制这些生物在牙菌斑中的植入，并可能对龋齿具有保护作用。

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