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首页> 外文期刊>Infection and immunity >Homogeneity of protein serotype antigens in Neisseria meningitidis group A.
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Homogeneity of protein serotype antigens in Neisseria meningitidis group A.

机译：脑膜炎奈瑟氏球菌A组中蛋白质血清型抗原的同质性。

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Serotype antigens (STA), which have been shown to be constituents of outer-membrane protein, were extracted from group A meningococci with 0.2 M LiCl and pelleted by centrifugation at 150,000 X g. The STAs from 100 group A strains, which had been isolated from cases and carriers in various geographical locations, were compared by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Every STA produced three major protein bands with molecular weights of approximately 35,000, 39,000, and 45,000, respectively. This SDS-PAGE pattern is clearly distinct from that produced by the serotype of group B and C meningococci most commonly isolated from cases (group B type 2 and group C type 2). The group A STAs were also indistinguishable by immunodiffusion. However, differences in bactericidal reactions were demonstrated, suggesting that there are other antigens that play a role in antibody response.
机译：血清型抗原（STA）已被证明是外膜蛋白的组成部分，是从A组脑膜炎球菌中提取的，含0.2 M LiCl，并通过150,000 X g离心沉淀。通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳（SDS-PAGE）比较了从不同地理位置的病例和携带者中分离出的100个A组菌株的STA。每个STA都会产生三个主要的蛋白条带，分别具有大约35,000、39,000和45,000的分子量。这种SDS-PAGE模式与B和C型脑膜炎球菌血清型最常见（从B型2型和C型2型）中分离出的模式明显不同。通过免疫扩散也无法区分A组STA。然而，已证明了杀菌反应的差异，表明还有其他抗原在抗体反应中起作用。

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