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首页> 外文期刊>Infection and immunity >Protective effect of glucan against systemic Staphylococcus aureus septicemia in normal and leukemic mice.
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Protective effect of glucan against systemic Staphylococcus aureus septicemia in normal and leukemic mice.

机译：葡聚糖对正常和白血病小鼠的全身性金黄色葡萄球菌败血病的保护作用。

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摘要

The reticuloendothelial stimulant glucan, a beta-1,3-polyglucose component of the cell wall of Saccharomyces cerevisiae, was evaluated for its ability to modify Staphylococcus aureus-induced lethality in normal and leukemic mice. In normal mice the intravenous injection of glucan (0.45 mg per mouse) 7 and 4 days prior to intravenous challenge with S. aureus (1.0 x 10(9)) resulted in a significantly increased survival. Histological examination of the kidneys revealed that glucan significantly inhibited renal necrosis associated with systemic staphylococcal diseases. Further studies indicated that glucan administration not only enhanced survival of leukemic mice, but also increased survival of leukemic mice with experimentally induced staphylococcal speticemia. These data denote that glucan enhances nonspecific resistance to S. aureus sepsis, promotes survival during leukemic episodes, and increases survival time of leukemic mice with experimentally induced staphylococcal infection.
机译：评价了网状内皮刺激物葡聚糖，酿酒酵母细胞壁的β-1,3-聚葡萄糖成分，以改变其在正常小鼠和白血病小鼠中对金黄色葡萄球菌诱导的致死性的修饰能力。在正常小鼠中，在用金黄色葡萄球菌（1.0 x 10（9））静脉内攻击前7天和4天静脉注射葡聚糖（每只小鼠0.45 mg）导致存活率显着提高。肾脏的组织学检查显示，葡聚糖可显着抑制与全身性葡萄球菌疾病相关的肾脏坏死。进一步的研究表明，给予葡聚糖不仅可以提高白血病小鼠的存活率，而且可以增加患有实验性葡萄球菌性血血症的白血病小鼠的存活率。这些数据表明，葡聚糖增强了对金黄色葡萄球菌败血症的非特异性抗性，促进了白血病发作期间的存活，并增加了患有实验性葡萄球菌感染的白血病小鼠的存活时间。

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