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首页> 外文期刊>Infection and immunity >Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentation.
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Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentation.

机译：影响白色念珠菌丝化的因素：白色念珠菌在丝化过程中呼吸活动的变化。

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摘要

Glucose metabolism and respiration of Candida albicans were compared under conditions which permitted either maximal filamentous or maximal yeast growth. Changes in metabolism were monitored by comparing the quantities of ethanol produced, CO2 evolved, and oxygen consumed. Filamenting cultures produced more ethanol and less CO2 than yeasts, with oxygen consumption in the former concomitantly slower than that of the latter. Studies involving cofactors and inhibitors associated with electron transport imply that a transfer of electrons away from flavoprotein is required for maintenance of yeast morphology. Conditions consistent with a buildup of reduced flavoprotein, however, favored filament formation. These changes were expressed metabolically as a shift from an aerobic to a fermentative metabolism. The results presented are consistent with hypotheses correlating filament production with changes in carbohydrate metabolism and an interruption of electron transfer within the cell.
机译：在允许最大丝状或最大酵母生长的条件下比较白色念珠菌的葡萄糖代谢和呼吸作用。通过比较产生的乙醇，释放的CO2和消耗的氧气来监测新陈代谢的变化。与酵母相比，长丝培养产生更多的乙醇和更少的CO2，前者的耗氧量比后者要慢。涉及与电子运输相关的辅因子和抑制剂的研究表明，维持黄酮蛋白的形态需要电子从黄素蛋白转移出来。然而，与减少的黄素蛋白积累相一致的条件有利于长丝形成。这些变化在代谢上表示为从有氧代谢到发酵代谢的转变。提出的结果与假说相关，假说将细丝生产与碳水化合物代谢变化以及细胞内电子转移中断相关联。

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