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首页> 外文期刊>Infection and immunity >Adhesive properties of Vibrio cholerae: nature of the interaction with intact mucosal surfaces.
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Adhesive properties of Vibrio cholerae: nature of the interaction with intact mucosal surfaces.

机译：霍乱弧菌的粘附特性：与完整粘膜表面相互作用的性质。

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Two companion papers in this series have characterized the interaction between Vibrio cholerae and the surfaces of eukaryotic cells. The present paper reports studies of the association between vibrios or Salmonella enteritidis and intact slices of intestinal tissue. A significant number of differences were noted in the characteristics of bacterial adhesion in these systems. The results are interpreted to indicate the presence of at least two receptors for vibrio adhesion on the mucosal surface of the rabbit small intestine. The receptor mediating the adhesion of salmonella appeared to be distinct from these. A primary role for bacterial motility in the process of adhesion of vibrios to mucosal surfaces could not be demonstrated in the assay systems studied. Rather, loss of motility in mutant vibrios appeared to be correlated with the simultaneous loss of adhesive factors (adhesins) from the bacterial surface. The inhibition of vibrio adhesion to slices of intestinal tissues by antibody to the heat-stable antigens of V. cholerae occurred in the absence of bacterial agglutination. Agglutination in this assay system appeared to be an artifact in that it could be observed only in experiments where extremely high concentrations of vibrios were used. We speculate that such high vibrio concentrations are not likely to be present in humans at the time of infection and that agglutination in the lumen of the intestine might therefore play only a minor role in prophylactic immunity against natural cholera and other enteric infections of humans.
机译：该系列的两篇伴随论文已经描述了霍乱弧菌与真核细胞表面之间的相互作用。本文报道了弧菌或肠炎沙门氏菌与完整的肠组织切片之间的关系的研究。在这些系统中，细菌粘附特性存在明显差异。结果被解释为表明在兔子小肠的粘膜表面上存在至少两个用于弧菌粘附的受体。介导沙门氏菌粘附的受体似乎与此不同。在研究的测定系统中无法证明细菌运动在弧菌与粘膜表面粘附过程中的主要作用。相反，突变型弧菌的运动力丧失似乎与细菌表面粘附因子（粘附素）的同时丧失有关。在没有细菌凝集的情况下，通过霍乱弧菌热稳定抗原的抗体抑制弧菌粘附到肠组织切片。该测定系统中的凝集似乎是伪影，因为只有在使用极高浓度弧菌的实验中才能观察到。我们推测在感染时人类中不太可能存在如此高的弧菌浓度，因此肠腔中的凝集可能在预防天然霍乱和人类其他肠道感染的免疫性中仅起次要作用。

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