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首页> 外文期刊>Infection and immunity >Reactivation of Chlamydia trachomatis lung infection in mice by cortisone.
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Reactivation of Chlamydia trachomatis lung infection in mice by cortisone.

机译：可的松可重新激活小鼠沙眼衣原体肺部感染。

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摘要

To study the latency, chronicity, and recurrent nature of chlamydial infection, we attempted to reactivate Chlamydia trachomatis lung infection in mice by immunosuppressive therapy with cortisone. Mice were treated with subcutaneous injections of cortisone acetate (125 mg/kg) every other day, starting on day 14 after intranasal inoculation of C. trachomatis serotype B (TW-5). C. trachomatis was recovered from the lungs beginning day 6 after the start of cortisone treatment until the end of the observation period on day 12 of treatment. Overall, the reactivation was successful in 8 of 55 mice treated with cortisone, in contrast to 0 of 41 inoculated, untreated mice (P = 0.009) and 0 of 35 uninoculated, treated mice. Cortisone treatment affected the ability of peritoneal exudate cells to respond to migratory inhibition after exposure to purified whole organisms of C. trachomatis serotype B (TW-5) but had little effect on serum antibody titers, indicating a possible role for cellular immunity in resistance against C. trachomatis infection in the lung.
机译：为了研究衣原体感染的潜伏期，慢性和复发性质，我们尝试通过可的松的免疫抑制疗法使小鼠沙眼衣原体肺部感染重新激活。从鼻内接种沙眼衣原体血清型B（TW-5）后第14天开始，每隔一天皮下注射醋酸可的松（125 mg / kg）对小鼠进行治疗。在开始可的松治疗后的第6天开始直至治疗的第12天观察期结束时，从肺中恢复了沙眼衣原体。总体而言，用可的松治疗的55只小鼠中有8只成功重新激活，与之相比，未接种的41只未治疗小鼠中有0只（P = 0.009），未接种的35只治疗小鼠中有0只。暴露于纯化的沙眼衣原体血清型B（TW-5）的完整生物后，可的松治疗影响腹膜渗出细胞对迁移抑制的反应能力，但对血清抗体滴度几乎没有影响，表明细胞免疫可能对抵抗肺炎沙眼衣原体感染。

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