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首页> 外文期刊>Infection and immunity >Role of cell-mediated immunity in the resolution of secondary chlamydial genital infection in guinea pigs infected with the agent of guinea pig inclusion conjunctivitis.
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Role of cell-mediated immunity in the resolution of secondary chlamydial genital infection in guinea pigs infected with the agent of guinea pig inclusion conjunctivitis.

机译：细胞介导的免疫在解决豚鼠包涵体结膜炎感染的豚鼠继发衣原体生殖器官感染中的作用。

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Guinea pigs which have recovered from a genital infection with the agent of guinea pig inclusion conjunctivitis demonstrate strong immunity to reinfection for a short period of time but then become susceptible to reinfection. The secondary infection is markedly shortened in duration and decreased in intensity. Previous studies have indicated an important role for humoral immunity in resistance to and in recovery from reinfection. However, the contribution of cell-mediated immunity to immunity toward or recovery from a secondary infection is not clear. Guinea pigs were infected in the genital tract with guinea pig inclusion conjunctivitis and were challenged at either 30 or 75 days after the primary infection. Prior to challenge, one group of animals were injected with rabbit anti-guinea pig thymocyte serum (ATS) while control groups received either normal rabbit serum or no treatment. Treatment was continued daily for the course of the experiment. On day 30, ATS-treated guinea pigs had a slightly higher rate of reinfection, and generally the infection persisted longer than in controls. On day 75, all animals became reinfected upon challenge, but control animals resolved their infections in 3 to 9 days. In contrast, most ATS-treated animals remained infected throughout the course of the experiment. Although the animals became reinfected, the levels of chlamydiae were much lower than those observed during the primary infection. ATS treatment abrogated T-cell responses, but serum and secretory antibody responses remained normal. Histopathological examination revealed some decrease in mononuclear infiltration of endocervical and uterine tissues in ATS-treated animals. These data indicate that previously infected guinea pigs require both cell-mediated immunity and humoral immunity for resolution of a challenge infection.
机译：从用豚鼠包涵体结膜炎的生殖器感染中恢复过来的豚鼠在短时间内表现出对再感染的强免疫力，但随后变得易于再感染。继发感染的持续时间明显缩短，强度降低。先前的研究表明体液免疫在抵抗再感染和从再感染中恢复中具有重要作用。然而，尚不清楚细胞介导的免疫对继发感染的免疫或从继发感染中恢复的贡献。豚鼠在生殖道中感染了豚鼠包膜结膜炎，并在初次感染后的30或75天接受了攻击。攻击前，向一组动物注射兔抗豚鼠胸腺细胞血清（ATS），而对照组则接受正常兔血清或不接受任何治疗。在实验过程中每天继续治疗。在第30天，ATS处理的豚鼠的再感染率略高，通常感染持续时间比对照组长。在第75天，所有动物在受到攻击后均被重新感染，但对照动物在3到9天内消除了感染。相反，在整个实验过程中，大多数经ATS治疗的动物仍然受到感染。尽管动物被再次感染，但衣原体的水平远低于初次感染时所观察到的水平。 ATS治疗废除了T细胞反应，但血清和分泌抗体反应仍然正常。组织病理学检查显示，在接受ATS治疗的动物中，宫颈内膜和子宫组织的单核浸润有所减少。这些数据表明，先前感染的豚鼠需要细胞介导的免疫力和体液免疫力才能解决挑战性感染。

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