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首页> 外文期刊>Infection and immunity >Tumor necrosis factor production in patients with leprosy.
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Tumor necrosis factor production in patients with leprosy.

机译：麻风病人的肿瘤坏死因子的产生。

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The spectrum of host responses to Mycobacterium leprae provides a model for investigating the role of cytokines in the pathogenesis of mycobacterial disease. Of particular interest is tumor necrosis factor (TNF), a cytokine which may have both antimycobacterial and immunopathologic effects. To evaluate the potential role of TNF in leprosy, we measured TNF production in response to M. leprae and its defined constituents by peripheral blood mononuclear cells from patients across the spectrum of disease. The levels of TNF induced through the stimulation of cells with M. leprae or its dominant "lipopolysaccharide," lipoarabinomannan, were higher in patients with the tuberculoid form of the disease than in those with the lepromatous form. In patients with erythema nodosum leprosum (ENL), a reactional state of lepromatous leprosy, the levels of TNF release by peripheral blood mononuclear cells were higher than in any other form of the disease. Treatment of ENL patients with thalidomide reduced TNF secretion by more than 90%. The mycolylarabinogalactan-peptidoglycan complex of Mycobacterium species, the protein-peptidoglycan complex, and muramyl dipeptide all elicited significant TNF release. Therefore, TNF release appears to be triggered by at least two major cell wall structural constituents of M. leprae, lipoarabinomannan and segments of the cell wall skeleton. The prominent TNF release in patients with the paucibacillary tuberculoid form of the disease compared with that in patients with the multibacillary lepromatous form suggests that this cytokine contributes to a resistant immune response to mycobacterial infection. However, the marked TNF release in patients with ENL indicates that TNF may also mediate immunopathologic effects, such as fever and tissue damage.
机译：宿主对麻风分枝杆菌的反应谱为研究细胞因子在分枝杆菌疾病发病机理中的作用提供了模型。特别令人感兴趣的是肿瘤坏死因子（TNF），一种可能同时具有抗分枝杆菌作用和免疫病理作用的细胞因子。为了评估TNF在麻风病中的潜在作用，我们测量了疾病谱系中患者外周血单个核细胞对麻风分枝杆菌及其定义的成分产生的TNF产生。在患有结核病的患者中，通过麻风分枝杆菌或其主要“脂多糖”脂阿拉伯糖甘露聚糖刺激细胞诱导的TNF水平高于麻风病形式的患者。在患有麻风性麻风的反应状态的结节性红斑麻风病（ENL）患者中，外周血单核细胞释放的TNF水平高于该疾病的任何其他形式。用沙利度胺治疗ENL患者可使TNF分泌减少90％以上。分枝杆菌属的分枝杆菌的半乳聚糖-肽聚糖复合物，蛋白质-肽聚糖复合物和鼠酰胺基二肽均引起了显着的TNF释放。因此，TNF的释放似乎是由麻风杆菌的至少两种主要细胞壁结构成分，脂阿拉伯糖甘露聚糖和细胞壁骨架的片段触发的。与多杆菌类麻风病患者相比，该疾病的结核杆菌型患者的TNF释放显着，表明该细胞因子有助于抵抗分枝杆菌感染的免疫反应。但是，ENL患者中明显的TNF释放表明TNF也可能介导免疫病理作用，例如发烧和组织损伤。

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