Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.

W C Kwan; W R McMaster; N Wong; N E Reiner

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Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.

机译：在多发性利什曼原虫感染的巨噬细胞中抑制主要组织相容性复合物II类分子的表达是通过循环AMP依赖性机制在基因转录水平发生的。

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Among the important pleiotropic responses to gamma interferon (IFN-gamma) during the activation of macrophages (M phi) is the increased expression of major histocompatibility complex class II genes. In the present study, infection with Leishmania donovani was shown to inhibit in parallel the induction by IFN-gamma of H-2 A beta gene transcription, class II mRNA accumulation, and H-2 Ad protein expression in cells of the murine macrophage cell line P388D1. Treatment of P388D1 cells with either the adenylate cyclase activator cholera toxin or the protein kinase A activator N6-2'-O-dibutyryl cyclic AMP (dibutyryl cAMP) similarly inhibited the induction by IFN-gamma of class II protein expression, and in parallel with Leishmania infection, cholera toxin inhibited the induction of mRNA for the H-2 A alpha and H-2 A beta proteins. Concentrations of intracellular cAMP were significantly increased in cholera toxin-treated cells but not in leishmania-infected cells. These findings indicate that at least one mechanism by which Leishmania infection attenuates the activation of M phi by IFN-gamma involves selective, transcriptional inhibition of major histocompatibility complex class II genes via a cAMP-independent mechanism.

机译：在巨噬细胞（M phi）激活过程中对γ干扰素（IFN-γ）的重要多效性反应中，主要的组织相容性复合物II类基因的表达增加。在本研究中，显示多发利什曼原虫感染可同时抑制鼠巨噬细胞系细胞中H-2 A beta基因转录，II类mRNA积累和H-2 Ad蛋白表达的IFN-γ诱导。 P388D1。用腺苷酸环化酶激活剂霍乱毒素或蛋白激酶处理P388D1细胞，激活剂N6-2'-O-二丁酰环状AMP（二丁酰cAMP）同样抑制IFN-γ诱导的II类蛋白表达，并与之平行。利什曼原虫感染，霍乱毒素抑制了H-2 A alpha和H-2 A beta蛋白的mRNA诱导。在霍乱毒素处理的细胞中，细胞内cAMP的浓度显着增加，而在利什曼原虫感染的细胞中则没有。这些发现表明利什曼原虫感染减弱IFN-γ对M phi的活化的至少一种机制涉及通过独立于cAMP的机制对主要组织相容性复合物II类基因的选择性转录抑制。

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《Infection and immunity》 |1992年第5期|共6页
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W C Kwan; W R McMaster; N Wong; N E Reiner;
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1. Cloning and expression of a Leishmania donovani gene instructed by a peptide isolated from major histocompatibility complex class II molecules of infected macrophages. [J] . A Campos-Neto, L Soong, J L Cordova, The Journal of Experomental Medicine . 1995,第5期

机译：从被感染巨噬细胞的主要组织相容性复合物II类分子中分离的肽指导的利什曼原虫多诺尼基因的克隆和表达。
2. Synthesis, stability, and subcellular distribution of major histocompatibility complex class II molecules in Langerhans cells infected with Leishmania major. [J] . S Flohé, T Lang, H Moll Infection and immunity . 1997,第8期

机译：主要组织相容性复合物II类分子在感染利什曼原虫的朗格汉斯细胞中的合成，稳定性和亚细胞分布。
3. Synthesis, stability, and subcellular distribution of major histocompatibility complex class II molecules in Langerhans cells infected with Leishmania major. [J] . S Flohé, T Lang, H Moll Infection and immunity . 1997,第8期

机译：主要组织相容性复合物II类分子在感染利什曼原虫的朗格汉斯细胞中的合成，稳定性和亚细胞分布。
4. Giant Panda Genomic Data Provide Insight into the Birth-and-Death Process of Mammalian Major Histocompatibility Complex Class II Genes [C] . Shengguo Fang Darwin 200 Beijing International Conference . 2010

机译：巨大的熊猫基因组数据可以深入了解哺乳动物主要组织相容性复合体II基因的出生和死亡过程
5. Role of Brahma related gene 1 in the transcription of the major histocompatibility complex class II genes. [D] . Mudhasani, Rajini Reddy. 2004

机译：梵天相关基因1在主要组织相容性复杂II类基因的转录中的作用。
6. Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism. [O] . W C Kwan, W R McMaster, N Wong, 1992

机译：在多发性利什曼原虫感染的巨噬细胞中抑制主要的组织相容性复合物II类分子的表达是通过循环AMP依赖性机制在基因转录水平发生的。
7. Cloning and expression of a Leishmania donovani gene instructed by a peptide isolated from major histocompatibility complex class II molecules of infected macrophages [O] . 1995

机译：从感染的巨噬细胞的主要组织相容性复合物II类分子中分离的肽指导的利什曼原虫多诺尼基因的克隆和表达
8. Molecular Analysis of the Induction of Class II Major Histocompatibility Antigen Expression on Murine Macrophages by Interferon-Gamma and Its Down-Regulation by Interferon-Alpha/Beta and Dexamethasone. [R] . Ruggio, D. F. 1989

机译：干扰素-γ诱导小鼠巨噬细胞II类主要组织相容性抗原表达的分子分析及干扰素-α/β和地塞米松的下调。

Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.

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