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首页> 外文期刊>Infection and immunity >Time Course and Host Responses to Escherichia coli Urinary Tract Infection in Genetically Distinct Mouse Strains
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Time Course and Host Responses to Escherichia coli Urinary Tract Infection in Genetically Distinct Mouse Strains

机译：在不同基因的小鼠品系中大肠杆菌泌尿道感染的时程和宿主反应

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Recurrent urinary tract infections (UTIs) are a significant clinical problem for many women; however, host susceptibility factors have not been completely defined. The mouse model of induced UTI provides an experimental environment in which to identify specific host characteristics that are important in initial bacterial colonization of the urinary tract and in resolution of an infection. This study examined initial susceptibility, bacterial clearance, and host defense mechanisms during induction and resolution of Escherichia coli UTIs in genetically distinct strains of mice. Of the ten inbred strains tested, six (BALB/c, C3H/HeN, C57BL/6, DBA.1, DBA.2, and AKR) showed progressive resolution of bladder infections over a 14-day period. A constant, low-level bladder infection was observed in SWR and SJL mice. High bladder infection levels persisted over the 14-day study period in C3H/HeJ and C3H/OuJ mice. Kidney infection levels generally correlated with bladder infection levels, especially in C3H/HeJ and C3H/OuJ mice, the two most susceptible strains, in which infections became more severe with time after challenge. The degree of inflammation in bladder and kidneys, as well as antibody-forming cell responses, positively correlated with infection intensity in all strains except C3H/HeJ, which had minimal inflammation despite high infection levels. These results demonstrate two important aspects of host defense against UTI. First, the innate immune response to an infection in the bladder or kidneys consists primarily of local inflammation, which is followed by an adaptive response characterized in part by an antibody response to the infecting bacteria. Second, a UTI will be spontaneously resolved in most cases; however, in mice with specific genetic backgrounds, a UTI can persist for an extended length of time. The latter result strongly suggests that the presence or absence of specific host genes will determine how effectively an E. coli UTI will be resolved.
机译：复发性尿路感染（UTIs）是许多女性的重要临床问题。但是，宿主易感性因素尚未完全定义。诱导的UTI的小鼠模型提供了一个实验环境，在其中可以鉴定对宿主的初步细菌定植和感染的消解至关重要的特定宿主特征。这项研究检查了在遗传上不同的小鼠品系中大肠杆菌 UTI的诱导和分解过程中的初始敏感性，细菌清除和宿主防御机制。在测试的十个自交系中，六个（BALB / c，C3H / HeN，C57BL / 6，DBA.1，DBA.2和AKR）在14天的时间内显示出逐渐解决的膀胱感染。在SWR和SJL小鼠中观察到恒定的低水平膀胱感染。在C3H / HeJ和C3H / OuJ小鼠的14天研究期内，高膀胱感染水平持续存在。肾脏感染水平通常与膀胱感染水平相关，尤其是在C3H / HeJ和C3H / OuJ小鼠中，这是两个最易感的品系，感染后随着时间的推移感染会变得更加严重。膀胱和肾脏的炎症程度以及抗体形成的细胞反应与除C3H / HeJ以外的所有菌株的感染强度呈正相关，C3H / HeJ尽管感染水平很高，但炎症最小。这些结果证明了针对UTI的宿主防御的两个重要方面。首先，对膀胱或肾脏感染的先天免疫应答主要由局部炎症组成，其后是适应性应答，其部分特征在于对感染细菌的抗体应答。其次，在大多数情况下，UTI会自发解决。但是，在具有特定遗传背景的小鼠中，UTI可以持续较长时间。后一个结果强烈暗示特定宿主基因的存在与否将决定 E的效率。大肠杆菌 UTI将得到解决。

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