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首页> 外文期刊>Infection and immunity >Effects of diet and genetics on Mycobacterium bovis BCG vaccine efficacy in inbred guinea pigs.
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Effects of diet and genetics on Mycobacterium bovis BCG vaccine efficacy in inbred guinea pigs.

机译：饮食和遗传学对近交豚鼠牛分枝杆菌BCG疫苗功效的影响。

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Strain 2 and strain 13 guinea pigs were vaccinated with Mycobacterium bovis BCG and placed on low-protein or protein-adequate diets. Five weeks later all animals were infected by the respiratory route with virulent Mycobacterium tuberculosis H37Rv organisms. Four weeks postchallenge, guinea pigs were skin tested with purified protein derivative and sacrificed. Protein deficiency resulted in significant reductions in body weight and thymus weight and in an impairment in the ability to control the M. bovis BCG vaccine organisms and to mount delayed hypersensitivity reactions. Protein deficiency also adversely affected the efficacy of the BCG vaccine as demonstrated by the numbers of virulent organisms recovered in spleens and lungs. Strain differences were observed in the number of leukocytes, thymus weight, and the responsiveness of blood lymphocytes to purified protein derivative stimulation. In general, strain 13 guinea pigs responded more dramatically to dietary insult than did their strain 2 counterparts. Protein deprivation completely abolished BCG vaccine protection in the lungs and spleens of strain 13 animals and significantly reduced the protection afforded to strain 2 animals. In both strains, the BCG vaccine protected normally nourished guinea pigs. There was no significant difference between strains with respect to susceptibility to pulmonary infection with virulent mycobacteria. Thus, diet and genetic pedigree each had a significant influence on BCG vaccine efficacy.
机译：用牛分枝杆菌BCG接种2号株和13号豚鼠，并饲喂低蛋白或蛋白充足的日粮。五周后，所有动物均通过呼吸道感染了强力结核分枝杆菌H37Rv生物。攻击后四周，用纯化的蛋白衍生物对豚鼠进行皮肤测试并处死。蛋白质缺乏症导致体重和胸腺重量显着降低，并且控制牛分枝杆菌BCG疫苗生物体和引起迟发性超敏反应的能力受到损害。蛋白质缺乏还对BCG疫苗的功效产生了不利影响，正如从脾脏和肺中回收的有毒生物的数量所证明的。在白细胞数量，胸腺重量和血液淋巴细胞对纯化的蛋白衍生物刺激的反应性中观察到了应变差异。一般而言，品系13的豚鼠对饮食侮辱的反应比品系2的猪更为强烈。蛋白质剥夺完全废除了对13号品系动物的肺和脾中BCG疫苗的保护，并显着降低了对2号品系动物的保护。在两种毒株中，卡介苗均保护正常营养的豚鼠。在毒力分枝杆菌对肺部感染的敏感性方面，菌株之间没有显着差异。因此，饮食和遗传谱系均对BCG疫苗效力产生重大影响。

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