Impairment of melibiose utilization in Streptococcus mutans serotype c gtfA mutants.

R G Barletta; R Curtiss

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Impairment of melibiose utilization in Streptococcus mutans serotype c gtfA mutants.

机译：变形链球菌血清型c gtfA突变体中黑芥子利用的损害。

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The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton sucrose-hydrolyzing enzyme. Analysis of S. mutans gtfA mutants revealed that the mutant strains were specifically impaired in the ability to use melibiose as a sole carbon source. S. mutans gtfA mutant strains synthesized less alpha-galactosidase activity inducible by raffinose than wild-type strains. Melibiose (an inducer in wild-type strains) failed to induce significant levels of alpha-galactosidase in the mutant strains. We hypothesize that melibiose use by S. mutans requires the interaction of the GtfA enzyme, or another gene product under the control of the gtfA promoter, with other gene product(s) involved in melibiose transport or hydrolysis.

机译：变形链球菌血清型c gtfA基因编码55-千达尔顿蔗糖水解酶。变形链球菌gtfA突变体的分析表明，该突变体菌株在使用黑芥子糖作为唯一碳源的能力上受到了特别的损害。变形链球菌gtfA突变菌株合成的棉子糖诱导的α-半乳糖苷酶活性比野生型菌株少。 Melibiose（野生型菌株的诱导剂）未能在突变菌株中诱导显着水平的α-半乳糖苷酶。我们假设变形链球菌使用黑芥子糖需要GtfA酶或gtfA启动子控制下的另一种基因产物与其他参与黑果糖运输或水解的基因产物的相互作用。

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《Infection and immunity》 |1989年第3期|共4页
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R G Barletta; R Curtiss;
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中图分类医学免疫学;
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1. Analysis of the virulence of Streptococcus mutans serotype c gtfA mutants in the rat model system. [J] . R G Barletta, S M Michalek, R Curtiss Infection and immunity . 1988,第2期

机译：大鼠模型系统中变形链球菌血清型c gtfA突变体的毒力分析。
2. Analysis of the virulence of Streptococcus mutans serotype c gtfA mutants in the rat model system. [J] . R G Barletta, S M Michalek, R Curtiss Infection and immunity . 1988,第2期

机译：大鼠模型系统中变形链球菌血清型c gtfA突变体的毒力分析。
3. Analysis of Loci Required for Determination of Serotype Antigenicity in Streptococcus mutans and Its Clinical Utilization [J] . Yukie Shibata, Kazuhisa Ozaki, Mitsuko Seki, Journal of Clinical Microbiology . 2003,第9期

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4. COMPARISON OF CAPSULAR POLYSACCHARIDE CONFORMATIONS IN STREPTOCOCCUS AGALACTIAE SEROTYPE III AND STREPTOCOCCUS PNEUMONIAE SEROTYPE 14: IMPLICATIONS FOR IMMUNOGENICS. [C] . Michelle M. Kuttel, Neil Ravenscroft International Carbohydrate Symposium . 2018

机译：链球菌血清型III和链球菌血管型血管型血管型血管型血管型血管型14的比较14：免疫学的影响。
5. Protective immunity against Streptococcus mutans infection: Studies on nirB promoter controlled expression of cloned S. mutans adhesin in an attenuated Salmonella strain and its immunoenhancing role on host immunity. [D] . Huang, Yan. 2001

机译：对变形链球菌感染的保护性免疫：在减毒沙门氏菌菌株中，nirB启动子控制克隆的变形链球菌黏附素表达的研究及其对宿主免疫的免疫增强作用。
6. Impairment of melibiose utilization in Streptococcus mutans serotype c gtfA mutants. [O] . R G Barletta, R Curtiss 3rd 1989

机译：变形链球菌血清型c gtfA突变体中黑芥子利用的损害。
7. Analysis of the virulence of Streptococcus mutans serotype c gtfA mutants in the rat model system [O] . R G Barletta, S M Michalek, R Curtiss 1988

机译：大鼠模型系统中链球菌血清型C GTFA突变体的毒力分析
8. Effects of Basic and Acidic Synthetic Polypeptides on the Adherence of the Oral Bacteria, Streptococcus Mutans and Streptococcus Sanguis, to Hydroxyapatite [R] . Lamberts, B. L., Pederson, E. D., Simonson, L. G. 1985

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Impairment of melibiose utilization in Streptococcus mutans serotype c gtfA mutants.

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