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首页> 外文期刊>Infection and immunity >CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract.
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CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract.

机译：CD4 + T细胞在对小鼠生殖道沙眼衣原体感染的过继免疫中起重要作用。

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摘要

The ability of CD4+ and CD8+ T cells to adoptively immunize mice against Chlamydia trachomatis infection of the mouse genital tract was studied. Adoptive transfer experiments were performed with splenic CD4+ or CD8+ T cells obtained from mice following resolution of a primary genital tract infection and after a secondary chlamydial challenge. The results show that donor CD4+ T cells, but not CD8+ T cells, obtained from mice following resolution of a primary infection or after secondary challenge were effective in transferring significant antichlamydial immunity to the genital tracts of naive animals. The lymphokine profiles in the culture supernatants of proliferating Chlamydia-specific CD4+ T cells obtained from mice following resolution of a primary infection and after secondary challenge were assayed by an enzyme-linked immunoadsorbent assay. Protective CD4+ T cells restimulated in vitro secreted interleukin 2, gamma interferon, and interleukin 6, lymphokine profiles characteristic of both Th1- and Th2-like responses. Resting CD4+ T cells obtained from mice 4 months following resolution of a primary infection were also capable of conferring significant levels of adoptive protective immunity to naive mice. These findings support an important role for CD4+ T cells in acquired immunity to chlamydial infection of the genital tract and indicate that protective CD4+ immune responses in this model are relatively long lived.
机译：研究了CD4 +和CD8 + T细胞过继免疫小鼠抵抗小鼠生殖道沙眼衣原体感染的能力。在原发性生殖道感染消退后和继发的衣原体感染后，对从小鼠获得的脾脏CD4 +或CD8 + T细胞进行过继转移实验。结果表明，原发性感染消退后或继发性攻击后从小鼠获得的供体CD4 + T细胞而非CD8 + T细胞可有效地将显着的抗衣原体免疫转移至幼稚动物的生殖道。在原发感染消退后和继发攻击后，从小鼠获得的增殖衣原体特异性CD4 + T细胞的培养上清液中的淋巴因子谱通过酶联免疫吸附测定进行了测定。在体外再刺激的保护性CD4 + T细胞分泌了Th1和Th2样反应的特征性白介素2，γ干扰素和白介素6。在原发感染消退后4个月，从小鼠获得的静息CD4 + T细胞也能够赋予幼稚小鼠显着水平的过继保护性免疫力。这些发现支持CD4 + T细胞在获得性生殖道衣原体感染的获得性免疫中的重要作用，并表明该模型中的保护性CD4 +免疫应答寿命相对较长。

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