Infectivity of Plasmodium bergheiSporozoites Delivered by Intravenous Inoculation versus Mosquito Bite: Implications for Sporozoite Vaccine Trials

Jefferson A. Vaughan; Libia F. Scheller; Robert A. Wirtz; Abdu F. Azad

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Infectivity of Plasmodium bergheiSporozoites Delivered by Intravenous Inoculation versus Mosquito Bite: Implications for Sporozoite Vaccine Trials

机译：静脉接种与蚊虫叮咬传递的伯氏疟原虫子孢子的感染性：对子孢子疫苗试验的意义。

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Plasmodium berghei sporozoites delivered by mosquito bite were more infectious to outbred CD-1 mice than were sporozoites delivered by intravenous inoculation. The route of challenge also affected vaccine efficacy. In view of these findings and the fact that mosquito bites are the natural mode of sporozoite delivery, infectious mosquito bites should be considered the challenge protocol of choice for sporozoite vaccine efficacy trials.

机译：与静脉注射的子孢子相比，蚊子叮咬的伯氏疟原虫对子代CD-1小鼠的传染性更高。攻击途径也影响疫苗效力。鉴于这些发现以及蚊子叮咬是子孢子传递的自然模式这一事实，传染性蚊虫叮咬应被视为选择子孢子疫苗功效试验的挑战性方案。 展开▼

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《Infection and immunity》 |1999年第8期|共5页

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Jefferson A. Vaughan; Libia F. Scheller; Robert A. Wirtz; Abdu F. Azad;
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中图分类医学免疫学;

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1. Plasmodium vivax Sporozoite Production in Anopheles albimanus Mosquitoes for Vaccine Clinical Trials [J] . Yezid Solarte, Maria R. Manzano, Leonardo Rocha, The American Journal of Tropical Medicine and Hygiene . 2011,第2Suppla期

机译：疟原虫间日疟原虫子孢子生产的疫苗临床试验。

2. A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation [J] . Murphy Sean C., Duke Elizabeth R., Shipman Kelly J., The Journal of Infectious Diseases . 2018,第5期

机译：一种随机试验，评估DSM265对蚊虫治疗人体疟疾感染期间对嗜血糖细胞疟原虫感染的预防活性，直接静脉接种

3. A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Pre-erythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation (vol 217, pg 693, 2018) [J] . Murphy The Journal of Infectious Diseases . 2018,第3期

机译：随机试验评估DSM265对蚊虫治疗人体疟疾感染期间DSM265对红细胞疟原虫感染的预防性活性（Vol 217，PG 693,2018）

4. Identification and quantitation of Plasmodium falciparum and Anopheles gambiae proteins from Plasmodium parasite infected mosquitoes [C] . Raghothama Chaerkady, Mobolaji Okulate, Kumaran Kandasamy, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：来自疟原虫感染蚊子的疟原虫和anophelesGambiae蛋白的鉴定和定量。

5. 1. Generation and characterization of mutants in the proteolytic processing site of the circumsporozoite protein (CSP) of Plasmodium berghei. 2. Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: A new tool to study mosquito and mammalian host interactions with malaria parasites. [D] . Natarajan, Ramya. 2006

机译：1.伯氏疟原虫环子孢子蛋白（CSP）的蛋白水解加工位点中突变体的产生和表征。 2.伯氏疟原虫子孢子荧光体和促红细胞生成前阶段：研究蚊子和哺乳动物宿主与疟原虫相互作用的新工具。

6. Note: Infectivity of Plasmodium berghei Sporozoites Delivered by Intravenous Inoculation versus Mosquito Bite: Implications for Sporozoite Vaccine Trials [O] . Jefferson A. Vaughan, Libia F. Scheller, Robert A. Wirtz, 1999

机译：注意：通过静脉接种与蚊虫叮咬传播的伯氏疟原虫子孢子的传染性：对子孢子疫苗试验的意义

7. Infectivity of Plasmodium berghei Sporozoites Delivered by Intravenous Inoculation versus Mosquito Bite: Implications for Sporozoite Vaccine Trials [O] . Jefferson A. Vaughan, Libia F. Scheller, Robert A. Wirtz, 1999

机译：静脉内接种与蚊子咬合术疟原虫孢子术的感染性：对孢子素疫苗试验的影响

8. Rapid, Large-Scale Isolation of Plasmodium berghei Sporozoites from Infected Mosquitoes [R] . Pacheco, N. D., Strome, C. P. A., Mitchell, F., 1978

机译：从受感染的蚊子中快速，大规模分离伯氏疟原虫子孢子

1. 免疫电镜观察定位于斯氏按蚊胃的伯氏疟原虫环子孢子蛋白及血小板反应素相关粘附蛋白 [J] . WutipongL ,邵红霞 ,毛佐华 . 国际医学寄生虫病杂志 . 2003,第003期

2. 冻存的伯氏疟原虫子孢子在体外培养中对培养细胞的感染力 [J] . . 首都医科大学学报 . 1986,第004期

3. 微小隐孢子虫子孢子表面蛋白CP15/60编码基因核酸疫苗的研究 [J] . 何宏轩 ,张西臣 ,尹继刚 . 中国农业科学 . 2003,第011期

4. 用微小隐孢子虫子孢子表面蛋白DNA疫苗免疫小鼠的实验研究 [J] . 何宏轩 ,张西臣 ,尹继刚 . 中国兽医杂志 . 2003,第002期

5. 约氏疟原虫红外期生物学特性及枯氏细胞活性对子孢子入侵影响的研究 [J] . 王兴相 ,黄复生 ,李全贞 . 传染病信息 . 1995,第002期

6. 常山对子孢子刺激鸡免疫细胞增殖和功能的影响 [C] . 田美杰 ,沈红 ,李秋明 . 第十一届北京畜牧兽医青年科技工作者“新思想新观点新方法”论坛 . 2015

7. 约氏疟原虫基因减毒子孢子疫苗保护性抗原的研究 [A] . 陈琳 . 2014

1. 作为疫苗及新疟疾疫苗和抗体结合靶标的疟原虫子孢子NPDP肽 [P] . 中国专利： CN110945022A . 2020-03-31

2. 体外生长的感染性疟原虫子孢子 [P] . 中国专利： CN106413746A . 2017-02-15

3. A COMPOSITION COMPRISING ISOLATED, METABOLICALLY ACTIVE, ATENTUATED PLASMODIUM SPOROZOITES SUITABLE FOR PARENTERAL NON INTRAVENOUS ADMINISTRATION OF AT LEAST ONE VACCINE DOSE TO A MAMMALIAN OR HUMAN HOST [P] . 外国专利： IN217420B . 2008-03-28

机译：包含隔离的，代谢活性的，诱变的疟原虫亚种组成的组合物，适合于至少一剂疫苗对哺乳动物或人类宿主的腹膜内非静脉内给药

4. A COMPOSITION COMPRISING ISOLATED, METABOLICALLY ACTIVE, ATENTUATED PLASMODIUM SPOROZOITES SUITABLE FOR PARENTERAL NON INTRAVENOUS ADMINISTRATION OF AT LEAST ONE VACCINE DOSE TO A MAMMALIAN OR HUMAN HOST [P] . 外国专利： IN2005KN01170A . 2006-05-12

机译：包含隔离的，代谢活性的，诱变的疟原虫亚种组成的组合物，适合于至少一剂疫苗对哺乳动物或人类宿主的腹膜内非静脉内给药

5. Insects of aseptic Anopheles species, sporozoites of aseptic Plasmodium species obtained therefrom and a vaccine comprising sporozoites of aseptic Plasmodium species [P] . 外国专利： ES2526347T3 . 2015-01-09

机译：无菌按蚊种的昆虫，从其获得的无菌疟原虫子孢子和包含无菌疟原虫种子孢子的疫苗

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Infectivity of Plasmodium bergheiSporozoites Delivered by Intravenous Inoculation versus Mosquito Bite: Implications for Sporozoite Vaccine Trials

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