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首页> 外文期刊>Infection and immunity >Gamma Interferon Production by Cytotoxic T Lymphocytes Is Required for Resolution of Chlamydia trachomatis Infection
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Gamma Interferon Production by Cytotoxic T Lymphocytes Is Required for Resolution of Chlamydia trachomatis Infection

机译：解决沙眼衣原体感染需要细胞毒性T淋巴细胞产生γ干扰素。

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In this study, we used mice in which the gene for gamma interferon (IFN-γ) has been disrupted (IFN-γ?/? mice) to study the role of this cytokine in the resolution of Chlamydia trachomatis infection. We show that IFN-γ?/? mice are impaired in the ability to clear infection with C. trachomatis compared to IFN-γ+/+ control mice. Activated CD8+ cytotoxic T lymphocytes (CTL) secrete IFN-γ in response to intracellular infection, and we have shown previously that a Chlamydia-specific CTL line can reduceC. trachomatis infection when adoptively transferred into infected mice. In the present study, we found that when these IFN-γ+/+ CTL lines are transferred intoChlamydia-infected IFN-γ?/? mice, the transferred CTL cannot overcome the immune defect seen in the IFN-γ?/? mice. We also show thatChlamydia-specific CTL can be cultured from IFN-γ-deficient mice infected with C. trachomatis; however, the adoptive transfer of IFN-γ?/? CTL into infected IFN-γ+/+ mice does not reduce the level of infection. These results suggest that IFN-γ production by CTL is not sufficient to overcome the defect that IFN-γ?/? mice have in the resolution of Chlamydia infection, yet IFN-γ production by CTL is required for the protective effect seen upon adoptive transfer of CTL into IFN-γ+/+ mice.
机译：在这项研究中，我们使用了其中干扰素（IFN-γ）基因已被破坏的小鼠（IFN-γ？/？小鼠），研究了这种细胞因子在解决< em>沙眼衣原体感染。我们表明，IFN-γ？/？小鼠清除 C感染的能力受损。沙眼与IFN-γ + / + 对照小鼠相比。活化的CD8 + 细胞毒性T淋巴细胞（CTL）响应细胞内感染而分泌IFN-γ，并且我们先前已经证明衣原体特异的CTL系可以降低 C。过继转移到受感染小鼠体内后会感染沙眼。在本研究中，我们发现当这些IFN-γ + / + CTL系转移到感染了衣原体的IFN-γ？/？小鼠中看到的免疫缺陷。我们还表明，衣原体特异性CTL可以从感染 C的IFN-γ缺陷小鼠中培养。沙眼;然而，将IFN-γ？/？ CTL过继转移到感染的IFN-γ + / + 小鼠中并不能降低感染水平。这些结果表明，CTL产生的IFN-γ不足以克服IFN-γ？/？小鼠在衣原体感染消退中所具有的缺陷，而IFN-γ将CTL过继转移到IFN-γ + / + 小鼠中所看到的保护作用需要CTL产生γ。

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