• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Identification and Characterization of the ESAT-6 Homologue of Mycobacterium leprae and T-Cell Cross-Reactivity with Mycobacterium tuberculosis
【24h】

Identification and Characterization of the ESAT-6 Homologue of Mycobacterium leprae and T-Cell Cross-Reactivity with Mycobacterium tuberculosis

机译：麻风分枝杆菌ESAT-6同源物的鉴定和表征以及与结核分枝杆菌的T细胞交叉反应

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this paper we describe identification and characterization of Mycobacterium leprae ESAT-6 (L-ESAT-6), the homologue of M. tuberculosis ESAT-6 (T-ESAT-6). T-ESAT-6 is expressed by all pathogenic strains belonging to the M. tuberculosis complex but is absent from virtually all other mycobacterial species, and it is a promising antigen for immunodiagnosis of tuberculosis (TB). Therefore, we analyzed whether L-ESAT-6 is a similarly powerful tool for the study of leprosy by examining T-cell responses against L-ESAT-6 in leprosy patients, TB patients, and exposed or nonexposed healthy controls from areas where leprosy and TB are endemic and areas where they are not endemic. L-ESAT-6 was recognized by T cells from leprosy patients, TB patients, individuals who had contact with TB patients, and healthy individuals from an area where TB and leprosy are endemic but not by T cells from individuals who were not exposed to M. tuberculosis and M. leprae. Moreover, leprosy patients who were not responsive to M. leprae failed to respond to L-ESAT-6. A very similar pattern was obtained with T-ESAT-6. These results show that L-ESAT-6 is a potent M. leprae antigen that stimulates T-cell-dependent gamma interferon production in a large proportion of individuals exposed to M. leprae. Moreover, our results suggest that there is significant cross-reactivity between T-ESAT-6 and L-ESAT-6, which has implications for the use of ESAT-6 as tool for diagnosis of leprosy and TB in areas where both diseases are endemic.
机译：在本文中，我们描述了 M的同源物麻风分枝杆菌 ESAT-6（L-ESAT-6）的鉴定和表征。结核病 ESAT-6（T-ESAT-6）。 T-ESAT-6由属于 M的所有致病菌株表达。结核病复合体，但实际上几乎所有其他分枝杆菌种中都没有，它是结核病（TB）免疫诊断的有希望的抗原。因此，我们通过检查麻风病人，结核病病人以及麻风病和麻风病地区暴露或未暴露的健康对照者的针对L-ESAT-6的T细胞反应，来分析L-ESAT-6是否是类似的研究麻风病的有力工具。结核病是地方病，不是地方病。 L-ESAT-6被麻风病患者，结核病患者，与结核病患者有接触的个体以及结核病和麻风病流行地区的健康个体的T细胞识别，但未被未暴露于< em> M。结核病和 M。麻风病。此外，对 M无反应的麻风病人。 leprae 对L-ESAT-6没有反应。使用T-ESAT-6获得了非常相似的模式。这些结果表明，L-ESAT-6是有效的 M。麻风杆菌抗原可在大部分暴露于 M的个体中刺激T细胞依赖性伽马干扰素的产生。麻风病。此外，我们的结果表明，T-ESAT-6和L-ESAT-6之间存在显着的交叉反应性，这暗示着在两种疾病都流行的地区，使用ESAT-6作为诊断麻风和结核病的工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号