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首页> 外文期刊>Infection and immunity >Aggregation of Streptococcus sanguis by a neuraminidase-sensitive component of serum and crevicular fluid.
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Aggregation of Streptococcus sanguis by a neuraminidase-sensitive component of serum and crevicular fluid.

机译：血清和宫颈液对神经氨酸酶敏感的成分聚集血链球菌。

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A number of strains of Streptococcus sanguis were found to aggregate in nonimmune serum and in crevicular fluid. All strains which aggregated in serum also aggregated in saliva, but some strains which aggregated in saliva did not aggregate in serum. Aggregation was destroyed by treatment of serum or crevicular fluid with neuraminidase and was inhibited by gangliosides. Treatment of serum with proteases reduced aggregating activity. Adsorption of serum to hydroxyapatite did not reduce the aggregating activity. The aggregating factor was partially purified by gel filtration and polyacrylamide gel electrophoresis and was found to be an acidic glycoprotein with a molecular weight of greater than 200,000, comprised of subunits with molecular weights of approximately 100,000. It did not appear to be an immunoglobulin and could not be identified with any other serum component tested. The possible role of the aggregating factor in providing nonimmune protection against colonization of S. sanguis in the gingival crevice and blood is discussed.
机译：发现许多血链球菌菌株在非免疫血清和子宫颈液中聚集。在血清中聚集的所有菌株也在唾液中聚集，但是在唾液中聚集的一些菌株在血清中不聚集。用神经氨酸酶处理血清或宫颈液可破坏聚集，并被神经节苷脂抑制。用蛋白酶处理血清降低了聚集活性。血清对羟基磷灰石的吸附不会降低聚集活性。聚集因子通过凝胶过滤和聚丙烯酰胺凝胶电泳进行了部分纯化，被发现是一种分子量大于200,000的酸性糖蛋白，由分子量约为100,000的亚基组成。它似乎不是免疫球蛋白，也无法与其他任何血清成分一起鉴定。讨论了聚集因子在针对牙龈裂隙和血液中的血丝链球菌定殖提供非免疫保护方面的可能作用。

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