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首页> 外文期刊>Infection and immunity >Immunological relationship between anionic antimicrobial proteins from caries-free individuals and known salivary antimicrobial factors.
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Immunological relationship between anionic antimicrobial proteins from caries-free individuals and known salivary antimicrobial factors.

机译：无龋个体的阴离子抗菌蛋白与已知唾液抗菌因子之间的免疫学关系。

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We examined whether the anionic inhibitory proteins identified in mixed saliva from certain caries-free individuals are fragments or degradation products of recognized salivary antimicrobial factors. In the experiments reported here, the anionic inhibitory proteins did not produce precipitin reactions with antisera to any of the established salivary antimicrobial factors examined. Additionally, native, heat-treated, or urea-denatured known salivary antimicrobial factors did not react with the antiserum to the anionic inhibitory proteins. However, the antiserum to the anionic inhibitory proteins was found to be reactive with a protein concentrate from mixed saliva or from separate submandibular and parotid secretions from a number of different donors, as well as with a purified protein fraction containing the homologous anionic inhibitory proteins. These findings suggest that the anionic inhibitory proteins represent intact and unique salivary proteins and not the degradation fragments of salivary antimicrobial protein factors within the oral environment.
机译：我们检查了从某些无龋者的混合唾液中鉴定出的阴离子抑制蛋白是否是公认的唾液抗菌因子的片段或降解产物。在此处报道的实验中，阴离子抑制蛋白不会对任何已确定的唾液抗菌因子产生与血清的沉淀素反应。另外，天然的，热处理的或尿素变性的已知唾液抗菌因子不会与阴离子抑制蛋白的抗血清反应。然而，发现对阴离子抑制蛋白的抗血清与混合唾液中的蛋白浓缩物或来自许多不同供体的单独的颌下和腮腺分泌物的蛋白浓缩物，以及与含有同源阴离子抑制蛋白的纯化蛋白组分反应。这些发现表明，阴离子抑制蛋白代表完整和独特的唾液蛋白，而不是口腔环境中唾液抗菌蛋白因子的降解片段。

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