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首页> 外文期刊>Infection and immunity >Streptococcus pneumoniae Damages the Ciliated Ependyma of the Brain during Meningitis
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Streptococcus pneumoniae Damages the Ciliated Ependyma of the Brain during Meningitis

机译：肺炎链球菌在脑膜炎期间损害脑纤毛室管膜

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Streptococcus pneumoniae meningitis remains a disease with a poor outcome for the patient. A region of the brain that has been neglected in the study of meningitis is the ependyma, which has been identified as a location of adult pluripotent cells. In this study we have used a rat model of meningitis to examine whether the ependymal layer is affected by S. pneumoniae. The effects included localized loss of cilia, a decrease of the overall ependymal ciliary beat frequency, and damage to the ependymal ultrastructure during meningitis. In conclusion, loss of ependymal cells and ciliary function exposes the underlying neuronal milieu to host and bacterial cytotoxins and this is likely to contribute to the neuropathology commonly observed in pneumococcal meningitis.
机译：肺炎链球菌脑膜炎仍然是一种疾病，对患者的预后不良。脑膜炎在脑膜炎的研究中被忽略的区域是脑室管膜，它已被确定为成人多能细胞的位置。在这项研究中，我们使用了脑膜炎的大鼠模型来检查室间隔层是否受 S影响。肺炎。其影响包括纤毛的局部丧失，整体室间隔睫状跳动频率的降低以及脑膜炎期间对室间隔超微结构的损害。总之，室管膜细胞和睫状功能的丧失使潜在的神经元环境暴露于宿主和细菌细胞毒素，这很可能有助于在肺炎球菌脑膜炎中常见的神经病理学。

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