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Pneumococcal Behavior and Host Responses during Bronchopneumonia Are Affected Differently by the Cytolytic and Complement-Activating Activities of Pneumolysin

机译：肺炎球菌肺炎球菌的行为和宿主反应受到肺炎球菌溶血素的细胞溶解和补体激活活性的不同影响

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摘要

Pneumolysin, a multifunctional toxin produced by all clinical isolates of Streptococcus pneumoniae, is strongly implicated in the pathogenesis of pneumococcal bronchopneumonia and septicemia. Using isogenic mutant strains, we examined the effect of deletion of the cytotoxic activity or complement-activating activity of pneumolysin on bacterial growth in lungs and blood, histological changes in infected lung tissue, and the pattern of inflammatory cell recruitment. Both of the activities of pneumolysin contributed to the pathology in the lungs, as well as the timing of the onset of bacteremia. Histological changes in the lungs were delayed after infection with either mutant compared to the changes seen after infection with the wild-type pneumococcus. The complement-activating activity of pneumolysin affected the accumulation of T cells, whereas the toxin's cytolytic activity influenced neutrophil recruitment into lung tissue.
机译：肺炎链球菌所有临床分离株产生的一种多功能毒素肺炎球菌溶血素，与肺炎球菌支气管肺炎和败血病的发病机理密切相关。使用同基因突变株，我们检查了肺炎球菌溶血素的细胞毒性活性或补体激活活性的缺失对肺和血液中细菌生长，感染的肺组织中组织学变化以及炎症细胞募集模式的影响。肺炎球菌溶血素的两种活性都导致了肺部的病理以及菌血症发作的时间。与野生型肺炎球菌感染后相比，任一种突变体感染后的肺组织学变化均被延迟。肺炎球菌溶血素的补体激活活性影响T细胞的积累，而毒素的溶细胞活性影响嗜中性白细胞募集进入肺组织。

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