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首页> 外文期刊>Infection and immunity >Use of parasite antigens and interleukin-2 to enhance suppressed immune responses during Trypanosoma cruzi infection in mice.
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Use of parasite antigens and interleukin-2 to enhance suppressed immune responses during Trypanosoma cruzi infection in mice.

机译：使用寄生虫抗原和白介素2增强克氏锥虫感染小鼠期间抑制的免疫反应。

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摘要

Mice infected with Trypanosoma cruzi exhibit an early and profound suppression of parasite-specific and nonspecific immune responses. Earlier studies have shown that this suppression is due, at least in part, to suppressor macrophages, deficiency in production of interleukin-2 (IL-2), and reduced T helper (Th)-cell activity. In the present study, the effect of exogenously supplied IL-2 on enhancement of parasite-specific Th-cell activity, anti-parasite immunoglobulin G (IgG) and IgM antibody levels, parasitemia, and longevity was examined in infected mice. The results showed that administration of IL-2 with and without antigenic stimulation with trinitrophenylated T. cruzi significantly enhanced parasite-specific IgM and IgG levels. Injection of IL-2 and trinitrophenylated T. cruzi together significantly enhanced parasite-specific Th-cell activity and was more effective in enhancement of parasite-specific antibody levels. In addition, it was found that IL-2 alone had a rapid and lasting effect in reducing parasitemia. These results suggest that deficiency in IL-2 may play a major role in host susceptibility to T. cruzi.
机译：克氏锥虫感染的小鼠表现出对寄生虫特异性和非特异性免疫反应的早期和深刻抑制。较早的研究表明，这种抑制作用至少部分是由于抑制性巨噬细胞，白细胞介素2（IL-2）产生不足以及T辅助（Th）细胞活性降低所致。在本研究中，在感染的小鼠中检查了外源提供的IL-2对寄生虫特异性Th细胞活性，抗寄生虫免疫球蛋白G（IgG）和IgM抗体水平，寄生虫血症和寿命的增强作用。结果表明，在有和没有抗原刺激的情况下，三硝基苯甲基克鲁维螺旋体的IL-2给药显着增强了寄生虫特异性IgM和IgG水平。 IL-2和三硝基苯基化的克鲁维酵母一起注射显着增强了寄生虫特异性Th细胞的活性，并且在增强寄生虫特异性抗体水平方面更有效。另外，发现单独的IL-2在减少寄生虫病方面具有快速和持久的作用。这些结果表明，IL-2的缺乏可能在宿主对克氏锥虫的易感性中起主要作用。

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