Expression and immune recognition of the conserved MSP4 outer membrane protein of Anaplasma marginale.

S M Oberle; G H Palmer; A F Barbet

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Expression and immune recognition of the conserved MSP4 outer membrane protein of Anaplasma marginale.

机译：Anaplasma marginale保守的MSP4外膜蛋白的表达和免疫识别。

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Defining conserved, protective epitopes is essential to the design of an effective vaccine against bovine anaplasmosis. MSP4, one of six initial body proteins recognized by a neutralizing serum, is conserved among Anaplasma marginale isolates at both the protein and the DNA levels. Sera from cattle immunized with an outer membrane fraction of A. marginale and protected from a virulent challenge bind MSP4. The gene for MSP4 has been cloned, and the recombinant protein has been expressed, isolated, and demonstrated to share epitopes with the native protein expressed on initial bodies. MSP4 may have a greater potential to protect cattle from a challenge by heterologous isolates than other A. marginale surface proteins, which vary widely in size and structure.

机译：定义保守的，保护性的表位对于设计针对牛无丝虫病的有效疫苗至关重要。 MSP4是被中和血清识别的六种初始机体蛋白之一，在无缘无核质分离株中，在蛋白质和DNA水平上都是保守的。来自牛的血清用边缘。曲霉的外膜部分免疫并保护免受强毒攻击后与MSP4结合。 MSP4的基因已被克隆，重组蛋白已被表达，分离并证明与在初始体上表达的天然蛋白共享表位。 MSP4可能比其他A.marginale表面蛋白具有更大的潜力，可以保护牛免受异源分离物的攻击，而A.marginale表面蛋白的大小和结构差异很大。

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《Infection and immunity》 |1993年第12期|共7页
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S M Oberle; G H Palmer; A F Barbet;
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6. Expression and immune recognition of the conserved MSP4 outer membrane protein of Anaplasma marginale. [O] . S M Oberle, G H Palmer, A F Barbet 1993

机译：Anaplasma marginale保守的MSP4外膜蛋白的表达和免疫识别。
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Expression and immune recognition of the conserved MSP4 outer membrane protein of Anaplasma marginale.

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