• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Immunoglobulin A (IgA), IgA1, and IgA2 antibodies to Candida albicans in whole and parotid saliva in human immunodeficiency virus infection and AIDS.
【24h】

Immunoglobulin A (IgA), IgA1, and IgA2 antibodies to Candida albicans in whole and parotid saliva in human immunodeficiency virus infection and AIDS.

机译：免疫球蛋白A（IgA），IgA1和IgA2抗人免疫缺陷病毒感染和AIDS中白念珠菌的整体和腮腺唾液的抗体。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human immunodeficiency virus (HIV)-infected individuals are predisposed to recurrent oral candidiasis, and, although it has been assumed that this is because of deficient mucosal immune responses, this has not been properly established. The present study aimed to compare the concentrations and secretion rates of immunoglobulin A (IgA) and IgA subclass antibodies to Candida albicans in whole and parotid saliva samples from HIV-infected patients, AIDS patients, and control subjects. Levels of IgA antibody to Candida species in whole saliva were higher in the HIV group than in the controls and were highest in the AIDS group (P < 0.05). In parotid saliva, the mean antibody levels were significantly greater in HIV-positive patients than in controls (P < 0.05) but fell to lower levels in the AIDS group. The secretion rates of Candida antibodies in parotid saliva were reduced in AIDS patients compared with HIV patients. The specific activities of the IgA antibodies and both subclasses were significantly higher in the HIV and AIDS patients than in the controls in both whole and parotid saliva (P < 0.05). Antibody levels were significantly correlated with the numbers of Candida organisms isolated from saliva (P < 0.05). These results suggest clear differences in salivary antibody profiles among HIV-infected. AIDS, and control subjects and are indicative of a response to antigenic challenge by infecting Candida species. No obvious defect in the mucosal immune response in the HIV or AIDS groups that might account for the increased prevalence of candidiasis was apparent.
机译：感染人类免疫缺陷病毒（HIV）的个体易患口腔念珠菌病反复发作，尽管人们认为这是由于粘膜免疫反应不足引起的，但尚未得到适当的证实。本研究旨在比较来自艾滋病毒感染患者，艾滋病患者和对照对象的完整和腮腺唾液样本中针对白色念珠菌的免疫球蛋白A（IgA）和IgA亚类抗体的浓度和分泌率。 HIV组中针对唾液念珠菌种类的IgA抗体水平高于对照组，而AIDS组最高（P <0.05）。在腮腺唾液中，HIV阳性患者的平均抗体水平显着高于对照组（P <0.05），但在AIDS组中降至较低水平。与HIV患者相比，AIDS患者腮腺唾液中念珠菌抗体的分泌率降低。在整个唾液和腮腺唾液中，HIV和AIDS患者的IgA抗体和这两个亚类的比活性均显着高于对照组（P <0.05）。抗体水平与从唾液中分离出的念珠菌数量显着相关（P <0.05）。这些结果表明HIV感染者唾液抗体谱存在明显差异。艾滋病和控制对象，通过感染念珠菌物种表明对抗原攻击的反应。在HIV或AIDS组中，粘膜免疫反应没有明显的缺陷，这可能是念珠菌病患病率上升的原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号