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首页> 外文期刊>Infection and immunity >Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice.
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Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice.

机译：芳香族和嘌呤依赖型鼠伤寒沙门氏菌的表征：注意力，持久性和诱导BALB / c小鼠保护性免疫的能力。

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摘要

Stable transposon-generated auxotrophic mutations in aroA, purA, and purE or aroA and purA together were introduced into Salmonella typhimurium strains which were virulent in mice. Strains harboring any of these mutations were attenuated when tested in BALB/c mice. purE strains were less attenuated than aroA or purA strains. Both aroA and purA mutants persisted for several weeks in the livers and spleens of the mice after intravenous infection, although the numbers of viable cells detected at various times after infection differed. aroA strains persisted at a higher level than purA strains and were effective live vaccines given intravenously or orally. purA strains were ineffective as oral vaccines and were poor intravenous vaccines. Strains harboring both aroA and purA mutations together were ineffective vaccines when administered orally or intravenously even though they persisted in the livers and spleens of the mice for long periods after intravenous infection.
机译：稳定转座子在aroA，purA和purE或aroA和purA中产生的营养缺陷型突变被引入鼠伤寒沙门氏菌菌株中，该菌株在小鼠中具有毒性。当在BALB / c小鼠中进行测试时，带有任何这些突变的菌株均被减弱。 purE菌株的衰减程度不及aroA或purA菌株。静脉感染后，aroA和purA突变体在小鼠的肝脏和脾脏中均持续了数周，尽管感染后不同时间检测到的活细胞数量有所不同。 aroA菌株比purA菌株持续存在的水平更高，是通过静脉或口服方式给予的有效活疫苗。 purA菌株作为口服疫苗无效，而静脉注射疫苗效果较差。口服或静脉内同时携带aroA和purA突变的菌株即使在静脉感染后长期存在于小鼠的肝脏和脾脏中，也是无效的疫苗。

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