首页> 外文期刊>Infection and immunity >Alteration of cytoplasmic Ca2+ in resting and stimulated human neutrophils by short-chain carboxylic acids at neutral pH.
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Alteration of cytoplasmic Ca2+ in resting and stimulated human neutrophils by short-chain carboxylic acids at neutral pH.

机译:在中性pH下,短链羧酸对静止和刺激的人类嗜中性粒细胞中胞质Ca2 +的改变。

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The results reported here indicate that the short-chain carboxylic acids acetate and propionate stimulate cytoplasmic calcium mobilization in human polymorphonuclear leukocytes, while butyrate and lactate do not. Together with the results of previous work, this indicates that there are at least three classes of short-chain carboxylic acids: those which can alter only cytoplasmic pH (e.g., lactic acid), those which can alter cytoplasmic pH and actin (e.g., butyric acid), and those which can alter cytoplasmic pH, actin, and calcium (e.g., acetate and propionate).
机译:此处报道的结果表明,短链羧酸乙酸盐和丙酸盐可刺激人多形核白细胞中的细胞质钙动员,而丁酸盐和乳酸盐则不。连同先前的研究结果,这表明至少存在三类短链羧酸:仅能改变细胞质pH的那些(例如乳酸),那些能改变细胞质pH和肌动蛋白的那些(例如丁酸)酸)以及可以改变细胞质pH,肌动蛋白和钙的物质(例如乙酸盐和丙酸盐)。

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