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首页> 外文期刊>Infection and immunity >Consequences of microbial attachment: directing host cell functions with adhesins.
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Consequences of microbial attachment: directing host cell functions with adhesins.

机译：微生物附着的后果：用粘附素指导宿主细胞功能。

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We take the view that adherence is not just a static process of holding hands but rather elicits a response in the targeted cell. From this point of view, adherence is an active process with an outcome. This outcome or fate is predictable only when several parameters of the host cell-adhesin interaction are known: is the adhesin acting alone or in series with other products, is the receptor up- or down-regulated at the time of ligation, which domain of the receptor is bound, and finally, which intracellular response circuits are connected to the receptor in the cell type targeted? Variations in these parameters are the basis for the ability of the adhesins of pathogens to orchestrate outcomes as disparate as simple address recognition versus actin nucleation, cytokine induction, activation of plasmin, derangement of leukocyte migration, or deposition of antibody on host cell membranes. The recognition of the relatedness of some eukaryotic and prokaryotic adhesive domains and the shared use of existing eukaryotic cell-cell interaction systems between host and pathogen suggest that the cellular interactions of interest in eukaryotic cell biology can be revealed by taking clues from the pathogens, which have studied and adapted to them the longest.
机译：我们认为遵守不仅是牵手的静态过程，而且还会在目标单元格中​​引起响应。从这个角度来看，遵守是一个积极的过程，并且有结果。仅当已知宿主细胞-粘附素相互作用的几个参数时，这种结果或命运才是可预测的：粘附素是单独起作用还是与其他产物串联起作用，在连接时受体是上调还是下调，受体被结合，最后，哪些细胞内应答回路与目标细胞类型的受体相连？这些参数的变化是病原体粘附素协调结果的能力的基础，其区别于简单的地址识别与肌动蛋白成核，细胞因子诱导，纤溶酶激活，白细胞迁移紊乱或抗体在宿主细胞膜上的沉积。对某些真核和原核粘附域的相关性的认识以及宿主与病原体之间现有真核细胞-细胞相互作用系统的共享使用表明，可以通过从病原体获取线索揭示真核细胞生物学中感兴趣的细胞相互作用。已经研究和适应了最长的时间。

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