Significant role of an exocellular protease in utilization of heme by Vibrio vulnificus.

Y Nishina; S Miyoshi; A Nagase; S Shinoda

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Significant role of an exocellular protease in utilization of heme by Vibrio vulnificus.

机译：胞外蛋白酶在创伤弧菌利用血红素中的重要作用。

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Clinical and environmental isolates of Vibrio vulnificus could grow in a synthetic medium supplemented with heme protein as the iron source. Protease-deficient mutants of the bacterium could not utilize any of the heme proteins in the synthetic medium, but the addition of purified V. vulnificus protease restored their growth. The protease digested all heme proteins tested and elicited heme liberation from the proteins. Furthermore, the induction of protease production by the heme proteins was demonstrated. These observations suggest that protease contributes to the efficient utilization of heme by V. vulnificus.

机译：弧菌弧菌的临床和环境分离株可以在补充有血红素蛋白作为铁源的合成培养基中生长。该细菌缺乏蛋白酶的突变体不能利用合成培养基中的任何血红素蛋白，但是添加纯化的创伤弧菌蛋白酶可以恢复其生长。该蛋白酶消化了所有测试的血红素蛋白，并引发了这些蛋白的血红素释放。此外，证明了血红素蛋白诱导蛋白酶产生。这些观察结果表明蛋白酶有助于V. vulnificus对血红素的有效利用。

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《Infection and immunity》 |1992年第5期|共5页
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Y Nishina; S Miyoshi; A Nagase; S Shinoda;
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中图分类医学免疫学;
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6. Significant role of an exocellular protease in utilization of heme by Vibrio vulnificus. [O] . Y Nishina, S Miyoshi, A Nagase, 1992

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Significant role of an exocellular protease in utilization of heme by Vibrio vulnificus.

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