Salivary receptors for GalNAc beta-sensitive adherence of Actinomyces spp.: evidence for heterogeneous GalNAc beta and proline-rich protein receptor properties.

N Str?mberg; T Borén; A Carlén; J Olsson

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Salivary receptors for GalNAc beta-sensitive adherence of Actinomyces spp.: evidence for heterogeneous GalNAc beta and proline-rich protein receptor properties.

机译：放线菌属的GalNAcβ敏感粘附的唾液受体：异质GalNAcβ和富含脯氨酸的蛋白受体特性的证据。

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The receptors for GalNAc beta 1-3Gal alpha Oethyl (GalNAc beta)-sensitive adherence of Actinomyces strains to salivary pellicles were investigated. Parotid and submaxillary saliva from one individual was size fractionated and utilized in hydroxyapatite adherence assays with Actinomyces naeslundii 12104 and A. viscosus 19246 and LY7 with and without GalNAc beta. Three parotid salivary fractions, the high-molecular-weight, acidic proline-rich protein (PRP), and statherin fractions, promote GalNAc beta-sensitive adherence of strain 12104, whereas only the high-molecular-weight fraction of submaxillary saliva promotes such adherence. In contrast, strain LY7, possessing a variant GalNAc beta specificity, shows GalNAc beta-sensitive adherence to the leading and trailing regions of the submaxillary PRP fractions but less distinct adherence to the parotid and submaxillary high-molecular-weight fractions. In addition, the PRP and statherin fractions promote adherence of strains LY7 and 19246 that is not inhibited by GalNAc beta. However, whereas strain LY7 binds more strongly to the PRP fraction than to the statherin fraction, strain 19246 binds preferentially to the statherin fractions of parotid and submaxillary saliva. These salivary protein fractions were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunostained to detect glycosylated proteins. The different salivary receptor properties are paralleled by different glycosylation patterns. The variable GalNAc beta specificities may have evolved to match different salivary glycosylation patterns, and PRP and statherin binding properties seem to be heterogeneous among the Actinomyces strains.

机译：研究了放线菌菌株对唾液薄膜的GalNAcβ1-3GalαOethyl（GalNAcβ）敏感粘附的受体。将来自单个个体的腮腺和颌下唾液按大小分级，并用于带有或不带有GalNAc beta的放线菌12104和粘液曲霉19246和LY7在羟磷灰石粘附试验中。三个腮腺唾液部分，即高分子量，酸性富含脯氨酸的蛋白质（PRP）和statherin部分，可促进菌株12104的GalNAcβ敏感粘附，而仅上颌下唾液的高分子量部分可促进这种粘附。。相反，具有变异的GalNAcβ特异性的LY7菌株显示对上颌下PRP组分的前导区和尾随区的GalNAcβ敏感粘附，但对腮腺和上颌下高分子量组分的粘附却不那么明显。此外，PRP和斯坦汀蛋白级分可促进LY7和19246菌株的粘附，而GalNAc beta不会抑制该粘附。但是，尽管菌株LY7与PRP组分的结合强度比其与Statherin组分的结合力更强，但菌株19246优先与腮腺和颌下唾液的Statherin组分结合。通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳分析这些唾液蛋白组分，并进行免疫染色以检测糖基化蛋白。不同的唾液受体特性与不同的糖基化模式平行。可变的GalNAcβ特异性可能已经演变为匹配不同的唾液糖基化模式，并且放线菌菌株之间的PRP和Steatherin结合特性似乎是异质的。

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《Infection and immunity》 |1992年第8期|共9页
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N Str?mberg; T Borén; A Carlén; J Olsson;
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1. Actinomyces tissue specificity may depend on differences in receptor specificity for GalNAc beta-containing glycoconjugates. [J] . N Str?mberg, T Borén Infection and immunity . 1992,第8期

机译：放线菌的组织特异性可能取决于含GalNAcβ的糖缀合物的受体特异性的差异。
2. Salivary Receptors for the Proline-rich Protein-binding and Lectin-like Adhesins of Oral Actinomyces and Streptococci. [J] . Ruhl S, Sandberg AL, Cisar JO Journal of Dental Research: Official Publication of the International Association for Dental Research . 2004,第6期

机译：唾液受体的口服放线菌和链球菌的脯氨酸丰富的蛋白质结合和凝集素样粘附素。
3. Adsorbed salivary proline-rich protein 1 and statherin: receptors for type 1 fimbriae of Actinomyces viscosus T14V-J1 on apatitic surfaces. [J] . R J Gibbons, D I Hay, J O Cisar, Infection and immunity . 1988,第11期

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5. Functional significance of glycoprotein clearance by the asialoglycoprotein receptor and the mannose/GalNAc-4-SO4 receptor. [D] . Steirer Taylor, Lindsay Michelle. 2009

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6. Salivary receptors for GalNAc beta-sensitive adherence of Actinomyces spp.: evidence for heterogeneous GalNAc beta and proline-rich protein receptor properties. [O] . N Strömberg, T Borén, A Carlén, 1992

机译：放线菌属的GalNAcβ敏感粘附的唾液受体：GalNAcβ和富含脯氨酸的蛋白受体特性不均的证据。
7. Different Type 1 Fimbrial Genes and Tropisms of Commensal and Potentially Pathogenic Actinomyces spp. with Different Salivary Acidic Proline-Rich Protein and Statherin Ligand Specificities [O] . Li, Tong, Khah, Massoud Kheir, Slavnic, Snjezana, 2001

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8. Co-Expression of Regulator of G Protein Signaling 4 (RGS4) and the MU Opioid Receptor in Regions of Rat Brain: Evidence That RGS4 Attenuates MU Opioid Receptor Signaling [R] . Crowder, A. T. 2003

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Salivary receptors for GalNAc beta-sensitive adherence of Actinomyces spp.: evidence for heterogeneous GalNAc beta and proline-rich protein receptor properties.

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