首页> 外文期刊>Infection and immunity >The RTX cytotoxin-related FrpA protein of Neisseria meningitidis is secreted extracellularly by meningococci and by HlyBD+ Escherichia coli.

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The RTX cytotoxin-related FrpA protein of Neisseria meningitidis is secreted extracellularly by meningococci and by HlyBD+ Escherichia coli.

机译：脑膜炎奈瑟氏球菌与RTX细胞毒素相关的FrpA蛋白由脑膜炎球菌和HlyBD +大肠杆菌分泌到细胞外。

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Neisseria meningitidis produces proteins (FrpA and FrpC) related to the RTX cytotoxin family. In meningococcal strain FAM20 these proteins were both localized in the outer membrane and secreted into the extracellular medium. An Escherichia coli strain with wild-type hemolysin secretion genes hlyB and hlyD and containing a cloned frpA gene secreted FrpA, whereas an isogenic hlyBD mutant strain did not. Low-stringency DNA hybridization revealed hlyBD-like sequences in N. meningitidis FAM20, suggesting that a similar RTX secretion system exists in meningococci. Structural features found at the C termini of other RTX proteins and thought to be important for their secretion were also found at the C terminus of FrpA. The secretion of FrpA from E. coli by heterologous RTX transport proteins further demonstrates the relation of the FrpA protein to RTX toxins.

机译：脑膜炎奈瑟氏球菌产生与RTX细胞毒素家族相关的蛋白质（FrpA和FrpC）。在脑膜炎球菌FAM20株中，这些蛋白都位于外膜中，并分泌到细胞外培养基中。具有野生型溶血素分泌基因hlyB和hlyD并含有克隆的frpA基因的大肠杆菌菌株分泌FrpA，而同基因的hlyBD突变菌株则没有。低严格性DNA杂交揭示了脑膜炎奈瑟氏球菌FAM20中的hlyBD样序列，表明在脑膜炎球菌中存在类似的RTX分泌系统。在其他RTX蛋白的C末端发现的结构特征，并认为对其分泌很重要，也在FrpA的C末端发现。异源RTX转运蛋白从大肠杆菌分泌FrpA进一步证明了FrpA蛋白与RTX毒素的关系。

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《Infection and immunity》 |1993年第7期|共6页
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S A Thompson; P F Sparling;
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中图分类医学免疫学;
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1. The RTX cytotoxin-related FrpA protein of Neisseria meningitidis is secreted extracellularly by meningococci and by HlyBD+ Escherichia coli. [J] . S A Thompson, P F Sparling Infection and immunity . 1993,第7期

机译：脑膜炎奈瑟氏球菌与RTX细胞毒素相关的FrpA蛋白由脑膜炎球菌和HlyBD +大肠杆菌分泌到细胞外。
2. Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. [J] . Kamal N, Shafer WM Antimicrobial agents and chemotherapy. . 2010,第1期

机译：通过在大肠杆菌中的功能互补评估脑膜炎奈瑟氏球菌的TolC样蛋白的生物活性。
3. Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: kinetic analysis of dihydropteroate synthases from N. meningitidis expressed in a knockout mutant of Escherichia coli. [J] . C Fermér, G Swedberg Journal of bacteriology . 1997,第3期

机译：适应脑膜炎奈瑟氏球菌对磺酰胺耐药性可能需要进行补偿性变化才能保留酶功能：在大肠杆菌的基因敲除突变体中表达的脑膜炎奈瑟氏菌二氢蝶呤合酶的动力学分析。
4. Investigation of iron-limitation inducible proteins of Neisseria meningitidis using the isobaric labelling approach tandem mass tags (TMT) [C] . Thorsten Prinz, Karsten Kuhn, Harald Legner, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：使用等离标记方法串联质量标签（TMT）对丝晶型脑膜炎的铁限制诱导蛋白的调查（TMT）
5. Topography, extracellular matrix proteins, secreted molecules and endogenous electric fields: Cues that influence the differentiation of neural progenitor cells. [D] . Ariza, Carlos Atico. 2009

机译：地形，细胞外基质蛋白，分泌的分子和内源性电场：影响神经祖细胞分化的线索。
6. The RTX cytotoxin-related FrpA protein of Neisseria meningitidis is secreted extracellularly by meningococci and by HlyBD+ Escherichia coli. [O] . S A Thompson, P F Sparling 1993

机译：脑膜炎奈瑟氏球菌与RTX细胞毒素相关的FrpA蛋白由脑膜炎球菌和HlyBD +大肠杆菌在细胞外分泌。
7. The RTX cytotoxin-related FrpA protein of Neisseria meningitidis is secreted extracellularly by meningococci and by HlyBD+ Escherichia coli [O] . S A Thompson, P F Sparling 1993

机译：Neisseria Meningitidis的RTX细胞毒素相关FRPA蛋白通过脑膜炎球菌和Hlybd +大肠杆菌分泌细胞外
8. Noncovalent Complex Vaccine, Prepared with Detoxified Escherichia coli J5 (RcChemotype) Lipopolysaccharide and Neisseria meningitidis Group B Outer Membrane Protein, Produces Protective Antibodies against Gram-Negative Bacteremia [R] . Bhattacharjee, A. K., Opal, S. M., Taylor, R., 1996

机译：非共价复合疫苗，用解毒的大肠杆菌J5（RcChemotype）脂多糖和脑膜炎奈瑟菌B组外膜蛋白制备，产生针对革兰氏阴性菌血症的保护性抗体

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