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首页> 外文期刊>Infection and immunity >Mechanisms involved in uptake of Bordetella bronchiseptica by mouse dendritic cells.
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Mechanisms involved in uptake of Bordetella bronchiseptica by mouse dendritic cells.

机译：小鼠树突状细胞摄取支气管博德特氏菌的机制。

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The invasion and intracellular survival of Bordetella bronchiseptica in mouse dendritic cells were investigated. The results obtained suggest that B. bronchiseptica binds specifically to glycosylated receptors present on the plasma membrane of dendritic cells, thereby inducing a signal that triggers an actin polymerization-dependent phagocytic process, probably via a protein kinase-dependent transducing phosphorylation signal. The energy required for the uptake process by host cells is provided mainly by the glycolytic pathway. An intact microtubule system and de novo protein synthesis in eukaryotic and prokaryotic cells are essential for efficient uptake and intracellular survival. The interaction of B. bronchiseptica with dendritic cells may be pertinent to natural infections that follow a chronic clinical course and predispose to secondary infections, and to the T-cell response involved in protective immunity following infections caused by Bordetella spp.
机译：研究了小鼠树突状细胞中支气管败血波氏杆菌的侵袭和细胞内存活。获得的结果表明，支气管败血性芽孢杆菌与树突状细胞的质膜上存在的糖基化受体特异性结合，从而诱导了信号，该信号触发了肌动蛋白聚合依赖性的吞噬过程，可能是通过蛋白激酶依赖性的磷酸化信号引起的。宿主细胞摄取过程所需的能量主要由糖酵解途径提供。真核细胞和原核细胞中完整的微管系统和从头蛋白质合成对于有效摄取和细胞内存活至关重要。支气管败血性博德特氏菌与树突状细胞的相互作用可能与遵循慢性临床病程并倾向于继发感染的自然感染有关，也与由博德特氏菌引起的感染后参与保护性免疫的T细胞反应有关。

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