• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Role of gamma interferon in a neonatal mouse model of group B streptococcal disease.
【24h】

Role of gamma interferon in a neonatal mouse model of group B streptococcal disease.

机译：γ干扰素在B组链球菌疾病的新生小鼠模型中的作用。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to assess the role of gamma interferon (IFN-gamma) in a neonatal mouse model of group B streptococcal (GBS) sepsis. IFN-gamma was produced by spleen cells at 24, 48, and 72 h after GBS challenge. Treatment with anti-IFN-gamma at 6 h before challenge totally abrogated the IFN-gamma response but did not affect survival. Subcutaneous administration of recombinant IFN-gamma (2,500 IU per pup) at 18 h after challenge resulted in increased survival time and reduced blood colony counts at 48 and 72 h. In vitro preincubation of neonatal whole blood with IFN-gamma before the addition of GBS resulted in significant restriction of bacterial growth. These data indicate that administration of recombinant IFN-gamma can partially restore impaired host defenses against GBS in neonatal mice. This cytokine may be useful for the treatment of neonatal infections.
机译：这项研究的目的是评估γ干扰素（IFN-γ）在B组链球菌（GBS）败血症的新生小鼠模型中的作用。在GBS攻击后24、48和72小时，脾细胞产生IFN-γ。在攻击前6小时用抗IFN-γ治疗完全消除了IFN-γ应答，但不影响存活。攻击后18 h皮下注射重组IFN-γ（每只幼犬2,500 IU）导致存活时间增加，并在48 h和72 h减少了菌落计数。在添加GBS之前，将新生全血与IFN-γ进行体外预​​培养会严重限制细菌的生长。这些数据表明，重组IFN-γ的施用可以部分恢复新生小鼠中受损的针对GBS的宿主防御能力。该细胞因子可用于治疗新生儿感染。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号