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首页> 外文期刊>Infection and immunity >Outer membrane protein B1, an iron-repressible protein conserved in the outer membrane of Moraxella (Branhamella) catarrhalis, binds human transferrin.
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Outer membrane protein B1, an iron-repressible protein conserved in the outer membrane of Moraxella (Branhamella) catarrhalis, binds human transferrin.

机译：外膜蛋白B1是卡他莫拉菌（Branhamella）卡他拉菌外膜中保守的铁可抑制蛋白，结合人转铁蛋白。

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Moraxella (Branhamella) catarrhalis is a gram-negative human mucosal pathogen, which primarily causes otitis media in young children. However, this bacterium is also a common cause of lower respiratory tract infections in adults with underlying lung disease. Our previous data have shown that M. catarrhalis expresses iron-repressible outer membrane proteins in response to iron limitation. We have extended these observations to demonstrate that one of these proteins, termed outer membrane protein (OMP) B1, binds human transferrin. Using a newly developed monoclonal antibody to OMP B1, we determined that this protein is conserved in the iron-stressed outer membranes of all clinical isolates of M. catarrhalis tested to date. Furthermore, our data have confirmed that children infected with M. catarrhalis have immunoglobulin G antibodies to OMP B1 in their convalescent sera. These current data suggest that OMP B1 is immunogenic and expressed in vivo and may be involved in an iron uptake mechanism utilized by M. catarrhalis.
机译：卡他莫拉菌（Branhamella）是革兰氏阴性人类粘膜病原体，主要引起幼儿中耳炎。但是，这种细菌也是引起基础肺部疾病的成年人下呼吸道感染的常见原因。我们以前的数据表明，卡他氏菌响应铁的限制表达铁可抑制的外膜蛋白。我们已经扩展了这些观察结果，以证明其中一种称为外膜蛋白（OMP）B1的蛋白与人转铁蛋白结合。使用一种新开发的针对OMP B1的单克隆抗体，我们确定该蛋白质在迄今测试的所有卡他莫拉氏菌临床分离株的铁胁迫外膜中均是保守的。此外，我们的数据已经证实，感染了卡他氏菌的儿童在恢复期的血清中具有针对OMP B1的免疫球蛋白G抗体。这些最新数据表明OMP B1具有免疫原性并在体内表达，并且可能参与了粘膜炎莫拉氏菌利用的铁吸收机制。

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