Inhibition of Neutrophil Apoptosis by Verotoxin 2 Derived from Escherichia coli O157:H7

Jiajia Liu; Tohru Akahoshi; Takeshi Sasahana; Hidero Kitasato; Rie Namai; Takeji Sasaki; Matsuhisa Inoue; Hirobumi Kondo

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Inhibition of Neutrophil Apoptosis by Verotoxin 2 Derived from Escherichia coli O157:H7

机译：源自大肠杆菌O157：H7的Verotoxin 2抑制中性粒细胞凋亡

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In order to evaluate the pathological role of verotoxin 2 (VT2), we investigated the effects of VT2 on neutrophil apoptosis in vitro. The results showed that VT2 caused a significant delay in spontaneous neutrophil apoptosis and that the effect was abrogated by a protein kinase C inhibitor. These data indicate that longer survival of neutrophils may aggravate neutrophil-mediated tissue damage in VT2-associated diseases.

机译：为了评估Verotoxin 2（VT2）的病理作用，我们研究了VT2对体外嗜中性白细胞凋亡的影响。结果表明，VT2导致自发性中性粒细胞凋亡的显着延迟，并且该作用已被蛋白激酶C抑制剂废止。这些数据表明，嗜中性粒细胞的更长生存期可能加剧与VT2相关的疾病中性粒细胞介导的组织损伤。

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《Infection and immunity》 |1999年第11期|共3页
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Jiajia Liu; Tohru Akahoshi; Takeshi Sasahana; Hidero Kitasato; Rie Namai; Takeji Sasaki; Matsuhisa Inoue; Hirobumi Kondo;
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中图分类医学免疫学;
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1. Bovine colostral antibody against verotoxin 2 derived from Escherichia coli O157:H7: resistance to proteases and effects in beagle dogs [J] . Kuribayashi T, Seita T, Matsumoto M, Comparative Medicine . 2009,第2期

机译：源自大肠杆菌O157：H7的针对牛毒素2的牛初乳抗体：对比格犬的蛋白酶抵抗及其作用
2. Bovine Colostral Antibody Against Verotoxin 2 Derived from Escherichia coli O157:H7: Resistance to Proteases and Effects in Beagle Dogs [J] . Kuribayashi Takashi, Seita Tetsuro, Matsumoto Mariko, Comparative Medicine . 2009,第2期

机译：源自大肠杆菌O157：H7的Verotoxin 2牛初乳抗体：对蛋白酶的抵抗力和对小猎犬的影响
3. Neutralizing activity of bovine colostral antibody against verotoxin derived from enterohemorrhagic Escherichia coli O157:H7 in mice. [J] . Kuribayashi T, Seita T, Fukuyama M, Journal of infection and chemotherapy: official journal of the Japan Society of Chemotherapy . 2006,第5期

机译：牛初乳抗体对小鼠肠出血性大肠杆菌O157：H7产生的维毒素的中和活性。
4. GLUTATHIONE AND CYSTEINE INHIBITION OF ALLYL ISOTHIOCYANATE ANTIMICROBIAL ACTIVITY AGAINST Escherichia coli O157:H7 [C] . ZHAO Qing, rnZHANG Shi, rnWANG Jun-lin, Proceedings of 53rd International Congress of Meat Science and Technology . 2007

机译：谷胱甘肽和半胱氨酸对大肠杆菌O157：H7的异硫氰酸烯丙酯的抑菌活性
5. Environmental stresses alter Escherichia coli O157:H7 membrane lipid composition and verotoxin secretion. [D] . Yuk, Hyun-Gyun. 2003

机译：环境压力会改变大肠杆菌O157：H7膜脂质组成和维毒素的分泌。
6. Note: Inhibition of Neutrophil Apoptosis by Verotoxin 2 Derived from Escherichia coli O157:H7 [O] . Jiajia Liu, Tohru Akahoshi, Takeshi Sasahana, 1999

机译：注意：源自大肠杆菌O157：H7的Verotoxin 2抑制嗜中性粒细胞凋亡
7. Horizontal transmission of Escherichia coli O157:H7 during cattle housing, survival kinetics in feces and water of Escherichia coli O157:H7 and characterisation of E. coli O157:H7 isolates from cattle faeces and a feedlot environment. [O] . Scott Lourda, McGee Philip, Sheridan Jim, 2005

机译：牛住房期间大肠杆菌O157：H7的水平传播，大肠杆菌O157：H7的粪便和水中的存活动力学以及来自牛粪便和饲养场环境的大肠杆菌O157：H7分离物的表征。

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Inhibition of Neutrophil Apoptosis by Verotoxin 2 Derived from Escherichia coli O157:H7

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