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首页> 外文期刊>Comparative Medicine >Bovine colostral antibody against verotoxin 2 derived from Escherichia coli O157:H7: resistance to proteases and effects in beagle dogs
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Bovine colostral antibody against verotoxin 2 derived from Escherichia coli O157:H7: resistance to proteases and effects in beagle dogs

机译：源自大肠杆菌O157：H7的针对牛毒素2的牛初乳抗体：对比格犬的蛋白酶抵抗及其作用

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摘要

A bovine colostral antibody against verotoxin (VT) 2 of Escherichia coli O157:H7 was administered orally to beagle dogs. The antibody remained in the dogs' small intestine for at least 2 h, whereas little serum antibody remained 1.5 h after administration. Furthermore, the antibody activity of secretory IgA did not change until 2 h after administration; however, the activity of IgG and IgM antibodies decreased by approximately 60% and 40% at 2 h after administration, respectively. Seven beagle dogs inoculated with Escherichia coli O157:H7 producing VT2 were administered bovine colostral antibody or bovine colostral whey without antibody. With administration of bovine colostral whey without antibody, the amount of VT2 in feces decreased gradually after administration and increased again at 5 d after inoculation, whereas bovine colostral antibody significantly reduced the amount of VT2 in feces on the day after administration. In addition, 9 beagle dogs were given bovine colostral antibody, bovine plasma antibody, or saline. The amount of VT2 in feces again decreased significantly more rapidly after administration of bovine colostral antibody than after administration of bovine plasma antibody or saline.
机译：向比格犬口服施用针对大肠杆菌O157：H7的Verotoxin（VT）2的牛初乳抗体。抗体在狗的小肠中保留至少2小时，而给药后1.5小时几乎没有血清抗体。此外，分泌型IgA的抗体活性直到给药后2小时才改变。然而，在给药后2小时，IgG和IgM抗体的活性分别下降了约60％和40％。给七只接种产生O2：大肠杆菌O157：H7的VT2的比格犬注射牛初乳抗体或不注射初乳的乳清。在不使用抗体的牛初乳中，粪便中的VT2量在给药后逐渐下降，并在接种后5 d再次增加，而在初次使用时牛初乳抗体显着减少了粪便中的VT2量。另外，对9只比格犬给予牛初乳抗体，牛血浆抗体或盐水。与施用牛血浆抗体或生理盐水后相比，施用牛初乳抗体后粪便中的VT2量再次显着更快地降低。

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