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首页> 外文期刊>Infection and immunity >Inflammatory Mediators in Dengue Virus Infection in Children: Interleukin-8 and Its Relationship to Neutrophil Degranulation
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Inflammatory Mediators in Dengue Virus Infection in Children: Interleukin-8 and Its Relationship to Neutrophil Degranulation

机译：儿童登革热病毒感染的炎症介体：白细胞介素8及其与中性粒细胞脱粒的关系。

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The chemokine interleukin-8 (IL-8) has chemoattractant activity for neutrophils and is able to activate and degranulate these cells. We investigated whether IL-8 may exert these effects in children with dengue virus infection. Circulating levels of IL-8, neutrophilic elastase (a constituent of the azurophilic granula of neutrophils), and lactoferrin, released from specific granula, were measured in 186 children with dengue virus infection, 33 healthy children as negative controls and 11 children with bacterial infections as positive controls. Levels of IL-8 on admission were elevated in 71% of the dengue patients, while the elastase and lactoferrin levels were increased in 68 and 17% of patients, respectively. These levels were significantly higher than in healthy children (P P = 0.02; WMW), but those of lactoferrin were not. IL-8 correlated with elastase and lactoferrin (r = 0.19 and P = 0.009 versus r = 0.24 and P = 0.001, respectively; two-tailed Spearman rank correlation). Thus, IL-8 levels are increased in most patients with dengue virus infection and correlate with degranulation of neutrophils as well as with some clinical and hemodynamic variables. These findings suggest a role for IL-8 in the pathogenesis of dengue virus infection.
机译：趋化因子白介素8（IL-8）对嗜中性粒细胞具有趋化性，并能激活和脱粒这些细胞。我们调查了IL-8是否会对患有登革热病毒感染的儿童发挥这些作用。在186例登革病毒感染儿童，33例健康阴性儿童和11例细菌感染儿童中测定了从特定颗粒中释放的IL-8，嗜中性弹性蛋白酶（嗜中性粒细胞嗜酸性颗粒的成分）和乳铁蛋白的循环水平。作为阳性对照。登革热患者入院时的IL-8水平升高，占登革热患者的71％，而弹性蛋白和乳铁蛋白的水平分别升高，分别为68％和17％。这些水平显着高于健康儿童（P P = 0.02; WMW），但乳铁蛋白则没有。 IL-8与弹性蛋白酶和乳铁蛋白相关（r = 0.19和P = 0.009，而r = 0.24和P = 0.001;两尾Spearman等级相关）。因此，在大多数登革热病毒感染患者中，IL-8水平升高，并与嗜中性粒细胞脱颗粒以及某些临床和血液动力学变量相关。这些发现提示IL-8在登革病毒感染的发病机理中的作用。

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