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首页> 外文期刊>Infection and immunity >Host and Tissue Specificity of Trichomonas vaginalis Is Not Mediated by Its Known Adhesion Proteins
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Host and Tissue Specificity of Trichomonas vaginalis Is Not Mediated by Its Known Adhesion Proteins

机译：阴道毛滴虫的宿主和组织特异性不由其已知的粘附蛋白介导。

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Adhesion of Trichomonas vaginalis is believed to be dependent on four adhesion proteins, which are thought to bind to vaginal epithelial cells in a specific manner with a ligand-receptor type of interaction. However, the specific receptors on the host cell have not yet been identified. In this work, the ability of the T. vaginalis adhesins to bind to cells of different histologic derivations and from different species has been studied. HeLa, CHO, and Vero cell lines; erythrocytes from different species; and a prokaryote without a cell wall, Mycoplasma hominis, were employed in order to investigate the cell specificity of the T. vaginalis adhesins. We observed that the T. vaginalisadhesins are able to bind to the different cell types to the same extent, suggesting that the host and tissue specificity of T. vaginalis adhesion should not be due to specificity of the parasite adhesins. Our results suggest that the data published to date on the subject are probably artifactual and that the experiments reported in the literature are not appropriate for identification of protozoan adhesins.
机译：据信阴道毛滴虫的粘附依赖于四种粘附蛋白，这些粘附蛋白被认为以特定的方式以配体-受体相互作用的方式与阴道上皮细胞结合。但是，尚未鉴定宿主细胞上的特异性受体。在这项工作中， T的能力。研究了阴道黏附素与不同组织学来源和不同物种的细胞结合的情况。 HeLa，CHO和Vero细胞系;不同物种的红细胞;为了研究 T的细胞特异性，采用了无细胞壁的原核生物 Myhoplasms 。阴道粘附素。我们观察到 T。阴道黏附素能够以相同程度结合不同的细胞类型，这表明 T具有宿主和组织特异性。阴道粘连不应归因于寄生虫粘附素的特异性。我们的结果表明，迄今发布的关于该主题的数据可能是人为的，并且文献中报道的实验不适用于鉴定原生动物粘附素。

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